靶向超声微泡在肝癌治疗领域的研究进展  

Advances of ultrasound targeted microbubbles in the field of liver cancer treatment

作　　者：张聪[1] 王玉凤[1] 李隆敏[1] 许桐瑛 朱文婷[1] 白玉贤[1] 谢蕊[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院消化内科,黑龙江哈尔滨150081

出　　处：《现代肿瘤医学》2017年第1期154-157,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年项目(编号:81401540);黑龙江省博士后特别资助(博士后青年英才计划)(编号:LBH-TZ0518)

摘　　要：在临床上现有的肝癌治疗方法为手术切除、射频消融、动脉栓塞化疗、无水酒精瘤内注射及肝移植等。靶向超声微泡的出现,拓展了传统肝癌的治疗思路,它不仅具有无创伤、无痛苦、无辐射、易重复使用的优点,还为药物和基因的靶向释放提供技术支持,并可以明显增强现有治疗方法的效果,在肝癌治疗方面展示出十分诱人的前景。本文就目前靶向超声微泡在肝癌治疗领域的机制与应用,以及存在的局限性和发展做一综述。Liver cancer,which has a high incidence,is one of the common malignant tumors in our country. The existing clinical treatments are surgical resection,radiofrequency ablation,liver transplantation,etc. The advent of ultrasound targeted microbubbles expands the traditional idea of liver cancer treatment and it has the advantages of no trauma,no pain,no radiation,and easy to repeated. This new technique provides technical support for targeted release of drugs and genes,and significantly enhances the effectiveness of existing treatments,which demonstrate attractive prospects in the treatment of liver cancer. In this paper,we present an overview of the mechanism and applications of ultrasound targeted microbubbles in the treatment of liver cancer,as well as its limitations and development.

关 键 词：肝癌 超声微泡 靶向治疗 

分 类 号：R735.7[医药卫生—肿瘤]