胆石症胆道感染患者血清IL-6、IL-8、TNF-α水平变化及临床意义分析  

Changes and clinical significances of serum IL-6,IL-8,and TNF-α levels in patients with cholelithiasis and biliary tract infection

作　　者：薛玉龙[1] 韩杰[1] 汪传一[1] 杨征宇[1] 辛永利[1] 

机构地区：[1]河南科技大学第三附属医院.洛阳东方医院普通外科二病区,河南洛阳471003

出　　处：《中华医院感染学杂志》2016年第24期5648-5650,共3页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划指导性计划项目(201411018)

摘　　要：目的探讨胆石症胆道感染患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)水平变化及临床意义,为胆石症并胆道感染的治疗提供参考。方法选取医院2014年10月-2015年10月住院治疗拟行手术治疗的胆石症患者100例,行手术治疗,在术中取胆汁进行细菌培养,术前(入院时)、术后3d检测血清IL-6、IL-8、TNF-α。结果 83例胆汁培养出病原菌,阳性率83.00%,共培养出89株病原菌,以革兰阴性菌为主,共56株占62.92%;患者术后3d血清IL-6、IL-8、TNF-α较术前明显下降,比较差异有统计学意义(P<0.05)。结论胆石症并胆道感染可引起血清IL-6、IL-8、TNF-α升高,手术治疗利于感染快速缓解,术前检测血清IL-6、IL-8、TNF-α对是否存在胆道感染有预测价值。OBJECTIVE To discuss changes and clinical significances of serum IL-6,IL-8,and TNF-αlevels in patients with cholelithiasis and biliary tract infection,so as to provide references for clinical treatment.METHODS A total of 100 cholelithiasis patients in the hospital prepared to be treated by surgery from Oct.2014 to Oct.2015 were selected.Bile bacteria were taken for culture during the surgery,and of the levels of serum IL-6,IL-8,and TNF-αbefore operation and 3days after operation were detected.RESULTS Totally 83 cases of bile cultured out pathogens,with the infection rate of 83.00%.There were 89 strains of pathogens,which were mainly 56 strains of gram-negative bacteria,accounting for 62.92%.Three days after operation,the levels of IL-6,IL-8,and TNF-αwere lower than those before operation,and the difference was significant（P〈0.05）.CONCLUSIONCholelithiasis and biliary tract infection can increase the levels of serum IL-6,IL-8,and TNF-α,surgical treatment is beneficial to the infection relief,and preoperative detection of the levels of serum IL-6,IL-8and TNF-αhad predictive value for the presence of biliary tract infection.

关 键 词：胆石症 胆道感染 白细胞介素-6 白细胞介素-8 肿瘤坏死因子Α 

分 类 号：R575.62[医药卫生—消化系统]