荧光显影+美蓝染色联合法对乳腺癌前哨淋巴结活检的诊断研究  

Combined fluorescent dye and methylene blue staining for detection of sentinel lymph nodes in early-stage breast cancer

作　　者：易瑛[1] 贾新建[1] 黄晓蓉[1] 蒋雪梅[1] 罗雪[1] 雷海[1] 

机构地区：[1]四川省德阳市人民医院乳腺外科,四川德阳618000

出　　处：《中国现代医学杂志》2016年第22期100-103,共4页China Journal of Modern Medicine

摘　　要：目的探讨荧光显影+美蓝染色联合法和美兰染色检测早期乳腺癌前哨淋巴结的对比效果。方法选取2014年1月-2015年1月德阳市人民医院住院确诊为乳腺癌的患者60例。随机平均分为两组,其中A组30例,采用单纯的美蓝染色检测早期乳腺癌前哨淋巴结;B组30例,采用荧光显影+美蓝染色联合法检测早期乳腺癌前哨淋巴结,同时做改良根治术,解剖腋窝获得腋窝淋巴结行病理检查,比较两种方法对早期乳腺癌前哨淋巴结的成功率及检出个数。结果 B组的成功率(88.89%)明显高于A组的成功率(66.67%),两两比较差异有统计学意义(P<0.05)。B组平均检出数目为2.60枚,明显高于A组1.70枚,P<0.05。结论采用荧光显影+美蓝染色联合法检测在早期乳腺癌前哨淋巴结检出率中具有较高的临床应用价值。Objective To investigate and compare methylene blue staining and joint fluorescence and methylene blue staining for detection of sentinel lymph node in early-stage breast cancer. Methods This study included 60 patients with early-stage breast cancer diagnosed in our hospital between January 2014 and January 2015. They were randomly divided into two groups. In group A （30 cases） simple methylene blue staining was used to detect sentinel lymph nodes. In group B （30 cases）, fluoroscopic visualization combined with methylene blue staining was used to detect of sentinel lymph nodes of early-stage breast cancer. Meawhile modified radical mastectomy was carried out, axillary lymph nodes were dissected for pathological examination. The successful rate of sentinel lymph node detection was compared between the two groups. Results The successful rate （88.89%） of sentinel lymph node detection in the group B was significantly higher than that （66.7%） in the group A, the difference was statistically significant （ P〈 0.05）. The average number of sentinel lymph nodes in the group B （2.60） was significantly higher than that （1.70） in the group A （ P〈 0.05）. Conclusions Joint methylene blue staining and fluorescence assay has high clinical value in early detection of sentinel lymph nodes of early-stage breast cancer.

关 键 词：美蓝染色 荧光显影 早期乳腺癌前哨淋巴结 病理检查 

分 类 号：R737.9[医药卫生—肿瘤]