阿曲生坦的合成研究  

Research on the Synthesis Process of Atrasentan

作　　者：张立颖[1] 刘旭亮[2] 孟庆荣[2] 

机构地区：[1]山东理工大学,山东淄博255049 [2]山东新华制药股份有限公司,山东淄博255086

出　　处：《山东化工》2016年第23期25-25,28,共2页Shandong Chemical Industry

摘　　要：本文对阿曲生坦的合成工艺进行了优化研究。以二正丁基胺为起始原料,经缩合、水解制得阿曲生坦成品,纯度大于98.5%,总收率大于75.0%。The paper was aimed to study the synthetic process of atrasentan. ItS prepared with dibutylamine as starting material through condensation and hydrolysis reactions. The average yield of atrasentan was more than 75.0% with a purity of 98.5%.

关 键 词：阿曲生坦 二正丁基胺 合成 

分 类 号：TQ463[化学工程—制药化工]