ABCD3评分系统联合危险因素预测短暂性脑缺血发作患者早期卒中风险的研究  

THE VALUE OF THE ABCD3 SCORE COMBINED WITH RISK FACTORS PREDICTING CEREBRAL INFARCTION IN PATIENTS WITH TRANSIENT ISCHEMIC ATTACK

作　　者：钟才[1] 韦英海[1] 吴振宏[1] 欧阳强[1] 蓝玉[1] 

机构地区：[1]广西医科大学附属民族医院神经内科,南宁530001

出　　处：《广西医科大学学报》2016年第6期999-1002,共4页Journal of Guangxi Medical University

摘　　要：目的:探讨ABCD3评分系统联合危险因素在预测短暂性脑缺血发作(TIA)患者早期卒中风险的价值。方法:选取120例TIA患者,根据TIA后是否发生脑梗死分为脑梗死组和非脑梗死组。比较两组各项临床指标差异,并利用多因素Logistic回归分析确定TIA后脑梗死的独立危险因素。将独立危险因素纳入评分系统,采用ABCD3评分联合危险因素进行TIA后脑梗死风险预测,并与ABCD3评分系统预测结果进行对比。结果:两组高血压、高血脂、糖尿病、高血压合并糖尿病、高血压合并冠心病、既往脑梗死或TIA史、血清同型半胱氨酸≥15μmol/L及血清C反应蛋白(CRP)≥8mg/L发生率比较,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析结果显示,血清同型半胱氨酸≥15μmol/L及血清CRP≥8 mg/L是TIA后发生脑梗死的独立危险因素(均P<0.05)。ABCD3联合危险因素评分的受试者工作特征(ROC)曲线下面积(AUC)优于ABCD3评分(P<0.05)。结论:ABCD3联合危险因素评分评估TIA后脑梗死风险的效果优于ABCD3评分系统,值得临床推广应用。Objective;To assess the value of the ABCD3 score combined with risk factors for predicting cerebral infarction in patients with transient ischemic attack （TIA）. Methods. 120 patients with TIA were enrolled and were divided into cerebral infarction and non-infarction groups according to whether cerebral infarction occurred at post-operation. The clinical data were collected and compared between the two groups, and the risk factors for cerebral infarction after TIA were assessed by multivariable logistic regression analysis. The value of ABCD3 score system combined with risk factors for predicting cerebral infarction after TIA was evaluated. Results： There were significant differences in the incidence of hypertension, hyperlipidemia, diabetes, hypertension combined with diabe- tes, hypertension combined with coronary artery disease, history of cerebral infarction or TIA, the serum homocysteine level ≥15μmol/L and serum C-reactive protein （CPR） level ≥8 mg/L between the two groups （ P 〈0.05）. Multiple logistic regression analysis showed that the serum homocysteine level ≥15 μmol/L and CRP level ≥8 mg/L were the independent risk factors for cerebral infarction after TIA. The receiver operating characteristic （ROC） curve manifested that the ABCD3 score combined with risk factors was superior to the ABCD3 score in predicting subsequent cerebral infarction in patients with TIA. Conclusion： The ABCD3 score combined with risk factors might enable prediction of cerebral infarction risk after TIA.

关 键 词：短暂性脑缺血发作 ABCD3评分系统 危险因素 同型半胱氨酸 C反应蛋白 

分 类 号：R743.31[医药卫生—神经病学与精神病学]