1-(1-氯环丙基)乙酮的工艺改进  

Process Improvement of 1-(1-Chloro-cyclopropyl) ethanone

作　　者：秦永其[1] 薛金辉[1] 张子锋[1] 

机构地区：[1]吕梁学院应用化学研究所,山西吕梁033001

出　　处：《农药》2016年第12期881-883,895,共4页Agrochemicals

基　　金：吕梁学院自然科学基金项目(ZRXN201501)

摘　　要：【目的】丙硫菌唑的重要中间体1-（1-氯环丙基）乙酮的合成方法改进，对其合成路线进行了优化。【方法】以α-乙酰基-γ-丁内酯为原料，采用“一锅法”完成氯代和水解反应，同时优化关环反应的影响因素，优化后的总收率达83．2％。【结果】产品结构经^1H NMR光谱鉴定为目标化合物。【结论】该工艺收率高、操作简便、产品纯度高，适合工业化生产。[Aims] 1-（1-Chloro-cyclopropyl）ethanone is an important intermediate ofprothioconazole, the paper aims to improve synthetic process of it. [Methods] Chloration and hydrolysis reaction were finished via an improved one-pot method from α-acetyl-γ-butyrolactone, and the influencing factors of cyclizationalso were optimized. Under the optimal conditions, the total yield was 83.2% based on a-acetyl-y-butyrolactoneand. [Results] The structure is characterized by ^1H NMR. [Conclusions] The process has some advantages of high yield, simple operation and high purity, which is suitable for industrial manufacture.

关 键 词：1-(1-氯环丙基)乙酮 一锅法 合成 

分 类 号：TQ455[化学工程—农药化工]