普罗布考片联合瑞舒伐他汀钙片治疗脑梗死并糖尿病患者的临床疗效  

Clinical Effect of Probucol Tablets Combined with Rosuvastatin Calcium Tablets in Treating Cerebral Infarction Patients Complicated with Diabetes

作　　者：滕海英[1] 毛媛媛[1] 季玉红[1] 

机构地区：[1]新疆生产建设兵团第十三师哈密红星医院神经内科,新疆维吾尔自治区哈密市839000

出　　处：《实用心脑肺血管病杂志》2016年第11期111-114,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察普罗布考片联合瑞舒伐他汀钙片治疗脑梗死并糖尿病患者的临床疗效。方法选取2015年2月—2016年2月新疆生产建设兵团第十三师哈密红星医院收治的脑梗死并糖尿病患者78例,按随机数字表法分为对照组与观察组,每组39例。两组患者入院后均予以常规治疗,对照组患者予以瑞舒伐他汀钙片治疗,观察组患者予以普罗布考片联合瑞舒伐他汀钙片治疗;两组患者均连续治疗6个月。比较两组患者治疗前后血脂指标〔三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)〕、S100β蛋白、美国国立卫生研究院卒中量表(NIHSS)评分、尿微量清蛋白、颈动脉内膜中层厚度(CIMT)、梗死面积,不良反应发生情况。结果治疗前两组患者TG、TC、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05);治疗后观察组患者TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05)。治疗前两组患者S100β蛋白、NIHSS评分、尿微量清蛋白水平比较,差异无统计学意义(P>0.05);治疗后观察组患者S100β蛋白、NIHSS评分、尿微量清蛋白水平低于对照组(P<0.05)。治疗前两组患者CIMT、梗死面积比较,差异无统计学意义(P>0.05);治疗后观察组患者CIMT、梗死面积小于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论普罗布考片联合瑞舒伐他汀钙片治疗脑梗死并糖尿病患者的临床疗效确切,可有效改善患者血脂代谢及神经功能,且安全性较高。Objective To observe the clinical effect of probucol tablets combined with rosuvastatin calcium tablets in treating cerebral infarction patients complicated with diabetes. Methods A total of 78 cerebral infarction patients complicated with diabetes were selected in Hami Hongxing Hospital of the 13th Division of Xinjiang Production and Construction Corps, and they were divided into control group and observation group according to random number table, each of 39 cases. Based on conventional treatment, patients of control group were given rosuvastatin calcium tablets, while patients of observation group were given probucol tablets combined with rosuvastatin calcium tablets; both groups continuously treated for 6 months. Blood liquids index （including TG, TC, LDL-C and HDL-C）, S10013 protein, NIHSS score, urine microalbumin, carotid intima media thickness （CIMT） and infarct area before and after treatment, and incidence of adverse reactions were compared between the two groups. Results No statistically significant differences of TG, TC, LDL-C or HDL-C was found between the groups before treatment （ P 〉 0. 05 ） ; after treatment, TG, TC and LDL-C of observation group were statistically significantly lower than those of control group, while HDL-C of observation group was statistically significantly higher than that of control group （ P 〈 0.05 ）. No statistically significant differences of S100β protein, NIHSS score or urine mieroalbumin was found between the two groups before treatment （P 〉 0. 05 ）, while S100β protein, NIHSS score and urine microalbumin of observation group were statistically significantly lower than those of control group after treatment （ P 〈 0. 05 ）. No statistically significant differences of CIMT or infarct area was found between the two groups before treatment （ P 〉 0. 05 ）, while CIMT and infarct area of observation group were statistically significantly smaller than those of control group （ P 〈 0. 05 ）. No statistically significant differences of i

关 键 词：脑梗死 糖尿病 普罗布考片 瑞舒伐他汀钙片 治疗结果 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]