非小细胞肺癌组织中E-cad、vegf表达与化疗表达疗效及预后相关性研究  

E-cad,VEGF Expression in Non-small Cell Lung Cancer and Chemotherapy Response and Prognosis Correlation

作　　者：王迪进[1] 李林[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2016年第12期1940-1943,1950,共5页The Practical Journal of Cancer

基　　金：江西省卫计委课题(编号:20155506)

摘　　要：目的分析E-cad、vegf在非小细胞肺癌中的表达及其与化疗疗效及非小细胞肺癌发生发展及预后的关系。方法非小细胞肺癌手术切除的病理样本共计30例,对这30例非小细胞肺癌样本采用免疫组织化学方法检测钙粘附蛋白E(E-cad)、血管内皮生长因子(vegf)的表达,采用多西他赛联合顺铂治疗,分析治疗有效率(ORR)、无进展生存时间(PFS)以及检测E-cad和vegf的表达,分析E-cad、vegf表达与疗效的关系。结果 E-cad、vegf表达水平与患者的一般资料如年龄、性别、以及肿瘤特征如大小、侵袭深度,肿瘤分期及分化程度、是否转移等并不存在相关性(P>0.05);而淋巴受累组E-cad相对表达量明显下调、vegf相对表达量明显上调(P<0.05),而无淋巴受累组的相对表达量与正常组相比差异无统计学意义(P>0.05),E-cad、vegf相对表达量明显上调与淋巴结受累转移的风险有关;多西他赛联合顺铂治疗后vegf高表达患者ORR为11.2%,PFS为2.1个月,均低于vegf低表达患者(ORR为46.3%,PFS为6.6个月)(P<0.05),E-cad高表达患者ORR为46.3%,PFS为6.6个月,与E-cad低表达患者(ORR为31.8%,PFS为3.5个月)(P<0.05)。结论 E-cad、vegf相对表达量水平与非小细胞肺癌的淋巴结转移及预后有一定的相关性,预后与vegf表达呈负相关,vegf低表达者有效率较高;与E-cad呈正相关,E-cad高表达者有效率较高,但还需进一步分析。Objective To study the expression of E-cad and VEGF in non-small cell lung cancer（NSCLC） and its rela-tionship with chemotherapy effect and development and prognosis of NSCLC. Methods 30 cases of sample tissues of NSCLC treated with general surgery were collected. Expression of E-cad and VEGF in these samples were detected by immunohistochemistry, and received docetaxel plus cisplatin treatment, therapeutic efficiency （ORR）, progression-free survival（PFS） and expression of E-cad and VEGF were analyzed. Correlation of E-cad,VEGF expression and treatment effect were analyzed. Results Expres- sion of E-cad and VEGF had no correlation with general information such as age, gender, and tumor characteristics including size, depth of invasion, tumor stage, differentiation, and metastasis （ P 〉 0.05 ） ; and in lymphatic involvement group, relative expression of E-cad significantly reduced, VEGF relative expression significantly increased （ P 〈 0.05 ）, without lymph node involvement group, relative expression had no statistically significant difference with the normal group （ P 〉0. 05 ）, E-cad, VEGF relative expression significantly increased with lymph node involvement metastasis risk;in patients with high VEGF expression after docetaxel plus cisplatin treatment, ORR was 11.2%, PFS was 2.1 months, which were lower than VEGF low expression patients （ ORR was 46.3% ,PFS was 6.6 months） （P 〈0.05） ,in patients with E-cad high expression,ORR was 46.3% ,PFS was 6.6 months, and E-cad low expression patients, ORR was 31.8 % PFS was 3.5 months （P 〈 0.05 ）. Conclusion Relative expression of E-cad and VEGF have a certain correlation with lymph node metastasis and prognosis, VEGF expression and prognosis are negatively correlated,VEGF low expression have higher effficiency;and E-cad expression and prognosis are positively correlated, E-cad high expression have a higher efficiency, but it needs further study.

关 键 词：非小细胞肺癌 E-cad、vegf 微血管密度 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]