人乳头瘤病毒的基因分型与宫颈腺癌的预后相关性研究  

Correlation of Human Papillomavirus Gene Type and Prognosis in Cervical Adenocarcinoma

作　　者：陈文学[1] 邹学森[1] 黄秀珍[1] 陈芸 

机构地区：[1]江西省肿瘤医院,330029 [2]江西省精神病院,330029

出　　处：《实用癌症杂志》2016年第12期1944-1946,共3页The Practical Journal of Cancer

基　　金：江西省卫计委课题(编号:20155417)

摘　　要：目的探讨人乳头瘤病毒不同的基因分型在宫颈腺癌中的表达情况及其对宫颈腺癌预后的影响。方法采用导流杂交的方法检测32例宫颈腺癌中HPV分型情况,分析不同的HPV基因分型与宫颈腺癌预后的关系。结果宫颈腺癌中HPV阳性率为71.9%,其中HPV18阳性10例(43.5%),HPV16阳性8例(34.8%),其他型感染5例(21.7%),HPV感染与年龄相关,与其他临床病理因素无相关性,单因素分析显示宫颈腺癌的预后与FIGO分期、病理分级、淋巴结是否转移及HPV分型有关,多因素分析显示HPV分型是宫颈腺癌单独的预后因素。结论 HPV基因分型是宫颈腺癌单独的预后因素,HPV18型感染者比HPV16型感染者预后差。Objective To investigate the expression of human papiUomavirus （HPV） gene type in cervical adenocarci-moma and its effect on prognosis. Methods HPV gene type were tested by genotyping chip system in 32 cervical adenocarci-moma. The relation of HPV gene type and the prognosis of cervical adenocarcinoma were analyzed. Results HPV positive rate of cervical adenocarcinoma was 71. 9%, among them HPV18 positive cases was 10 （ 53. 5% ）, HPV16 positive cases was 8（34.8% ） ,the infection cases of other type was 5（21.7% ）. HPV infection is relate to age and was not related to other clinico- pathologic characteristics. Univariate analysis showed that the prognosis of cervical adenocarcinoma was related to FIGO stage, pathological classification,lymph node metastasis and HPV gene type, multivariate analysis showed that HPV gene type was independent prognosis factors of cervical adenocarcinoma. Conclusion HPV gene type is independent prognosis factors of cervical adenocarcinoma, HPV18 gene type infection has poorer prognosis than HPV16 gene type infection

关 键 词：宫颈腺癌 人乳头瘤病毒 预后 

分 类 号：R737.33[医药卫生—肿瘤]