经尿道膀胱肿瘤电切术后三种化疗方案治疗浅表性膀胱癌的疗效及安全性比较  

Comparison of Efficacy and Safety among 3 Kinds of Chemotherapy Regimens for Superficial Bladder Cancer after Transurethral Resection of Bladder Tumor

作　　者：兰海河 张战宏[1] 胡新红[1] 

机构地区：[1]陕西省汉中市中心医院,723000

出　　处：《实用癌症杂志》2016年第12期2044-2046,共3页The Practical Journal of Cancer

摘　　要：目的对比分析经尿道膀胱肿瘤电切术后不同化疗方案治疗浅表性膀胱癌的疗效及安全性。方法回顾分析220例浅表性膀胱癌患者的临床资料,所有研究对象均接受经尿道膀胱肿瘤电切术治疗。根据术后化疗方案将患者分为A组(131例)、B组(40例)、C组(49例)。A组采用膀胱灌注化疗,B组采用髂内动脉化疗,C组患者膀胱灌注化疗联合髂内动脉化疗。化疗结束后,所有患者均接受随访。结果①3组患者1年复发率、3年复发率相比差异无统计学意义(P>0.05)。②3组患者全身不良反应分级差异有统计学意义(P<0.05)。A组全身不良反应分级显著低于B组、C组(P<0.05),B组与C组全身不良反应分级差异无统计学意义(P>0.05)。③3组患者化学性膀胱炎分级差异有统计学意义(P<0.05),B组化学性膀胱炎分级显著低于A组、C组(P<0.05),A组与C组化学性膀胱炎分级差异无统计学意义(P>0.05)。结论 3种术后化疗方案治疗浅表性膀胱癌患者的复发率相当,但是在不良反应方面有所区别,膀胱灌注化疗的全身不良反应较轻,髂内动脉化疗的化学性膀胱炎较轻。Objective To compare the efficacy and safety among different kinds of postoperative chemotherapy regimens in the treatment of patients with superficial bladder cancer who received transurethral resection of bladder tumor. Methods Clin- ical data of 220 cases of superficial bladder cancer were analyzed retrospectively, and all patients were given transurethral resec- tion of bladder tumor. According to their postoperative chemotherapy regimens, patients were divided into group A （ 131 cases）, group B （40 cases） and group C （49 cases）, and group A was given bladder perfusion chemotherapy, while group B and group C were given internal iliac artery chemotherapy, bladder perfusion chemotherapy plus internal iliac artery chemotherapy, respectively. All patients were followed up after postoperative chemotherapy regimen. Results ①No statistical differences were found in 1- and 3-year recurrence rates among the 3 groups（ P 〉 0.05 ）.②There were statistical differences in grading of systemic adverse reactions among the 3 groups （ P 〈 0.05 ）, and the grading in group A were statistically lower than those of group B and group C （ P 〈 0.05 ）, while no statistical differences were found between group B and group C （ P 〉 0.05 ）. ③There were statistical differences in grading of chemical cystitis among the 3 groups（P 〈 0.05 ） , and the grading in group B were statistically lower than those in group A and group C （ P 〈 0.05 ）, while no statistical differences were found between group A and group C （ P 〉 0.05 ）. Conclusion The 3 kinds of postoperative chemotherapy regimens have similar recurrence rate in the treatment of patients with superficial bladder cancer, but there are differences in the aspect of adverse reactions, and bladder perfusion chemotherapy shows lighter systemic adverse reactions, while internal iliac artery chemotherapy shows lighter chemical cystitis.

关 键 词：浅表性膀胱癌 经尿道膀胱肿瘤电切术 膀胱灌注化疗 髂内动脉化疗 

分 类 号：R737.14[医药卫生—肿瘤]