结直肠癌与膳食纤维相关饮食因素病例对照研究  

Association of dietary fiber intake with colorectal cancer: a matched casecontrol study

作　　者：袁平[1,2] 李文燕 林修全[1,2] 杨眉[4] 刘星[5] 陈仲武[6] 林仲[1,2] 陈铁晖[1,2] 林永添[4] 王慧[2] 

机构地区：[1]福建省疾病预防控制中心质管科,福州350001 [2]福建医科大学公卫学院教学基地 [3]福建省卫生计生人才服务与对外交流合作中心 [4]福建省肿瘤医院 [5]福建医科大学附属协和医院 [6]福建医科大学附属第一医院

出　　处：《中国公共卫生》2016年第12期1719-1723,共5页Chinese Journal of Public Health

基　　金：福建省自然科学基金(2013J01269)

摘　　要：目的 探讨膳食纤维相关饮食因素与结直肠癌发病风险之间的关系。方法 2013年12月—2015年12月以福建省肿瘤医院、福建医科大学附属协和医院和附属第一医院确诊的结直肠癌患者200例为病例组,同时选择与之在年龄、性别、地区等相匹配的健康居民200人作为对照组。运用1：1匹配病例对照研究,采用半定量食物频率调查问卷对调查对象进行面对面流行病学调查。结果 最近1年摄入甘薯纤维量（0.030-0.313 g/d OR=0.159,95%CI=0.042-0.608）、10年前摄入甘薯膳食纤维量（0.091-0.904 g/d OR=0.050,95%CI=0.009-0.269;〉0.904 g/d OR=0.186,95%CI=0.043-0.809）、地瓜干膳食纤维量（〉0.002 g/d OR=0.336,95%CI=0.177-0.628）、豆制品膳食纤维量（0.966-1.481 g/d OR=0.233,95%CI=0.079-0.681;〉1.481 g/d OR=0.043,95%CI=0.011-0.169）、性格类型（非A非B型性格OR=0.089,95%CI=0.025-0.319;B型性格OR=0.253,95%CI=0.080-0.800）是结直肠癌发病的保护因素;牛羊肉（1.645-14.247 g/d OR=10.025,95%CI=1.970-51.020;〉14.247 g/d OR=9.178,95%CI=1.386-60.791）、静态时间长（6-10 h OR=7.968,95%CI=1.901-33.402;〉10 h OR=21.225,95%CI=3.966-113.600）是结直肠癌发病的危险因素。结论 膳食纤维具有预防结直肠癌的作用,在日常生活中应注意调整饮食结构和生活方式。Objective To explore the relationship between dietary fiber intake and colorectal cancer （CRC） risk and to provide a basis for the prevention of colorectal cancer. Methods Totally 200 permanent Fujian province residents pathologically diagnosed with CRC first time and hospitalized in Fujian Province Tumor Hospital, Union Hospital and The First Hospital Affiliated to Fujian Medical University were recruited and 200 age-, gender-, and living area-matched healthy residents were selected as the controls. All participants were face-to-face interviewed with a self-designed questionnaire on demography,lifestyle, and semi-quantitative food intake frequency from December 2013 through December 2015. The collected data were analyzed with univariate analysis and multivariate conditional logistic regression. Results The average age of the cases （ 123 males and 77 females） was 58.13 ± 10.47 years and that of the controls （ the same numbers of the male and female as the cases） was 58.04 ± 10. 45 years. The results of multivariate logistic regression analysis revealed that the protective factors of CRC included with average sweet potato fiber intake of 0. 031 - 0. 313 gram/per day （g/d） （odds ratio[ OR] =0. 159,95% confidence intervalE95% CII ：0. 042 -0. 608） and 〉0. 313 g/d （OR =0. 159,95% CI：0. 082 -1. 256） compared with the intake of ≤0. 030 g/d in previous one year,with average sweet potato fiber intake of 0. 091 - 0. 904 g/d （ OR = 0. 050,95 % CI;O. 009 - 0. 269） and 〉 0. 904 g/d （ OR = 0. 186, 95% CI：O. 043 -0. 809） compared with the intake of ≤0. 090 g/d ten years ago,with dried sweet potato fiber intake of 〉0. 002 g/d （OR =0. 336,95% CI =0. 177 -0. 638） compared to without the intake of 〈0. 002 g/d,with soy fiber in- take of 0. 966 -1. 481 g/d （OR =0.233,95%CI：0.079-0.681） and 〉1.481 g/d OR =0.043 （95%CI：0.011- 0. 169） compared with the intake of ≤ 0. 965 g/d,and with the personality type of non A and non B （ OR =0. 089,95% CI=0. 025 -0. 319） and

关 键 词：结直肠癌 膳食纤维 病例对照研究 LOGISTIC回归 

分 类 号：R181.24[医药卫生—流行病学]