Synthesis of Novel 3-Substituted PyridothienopyrimidineDerivatives with Biological Evaluation as Antimicrobial Agents  

作　　者：Farag A. E1-Essawy Nader M. Boshta Ayman K. EI-Sawaf Areal A. Nassar Mohamed S. Khalafalah 

机构地区：[1]Preparatory Year Deanship, Basic Science Department, Prince Sattam Bin Abdulaziz University, KSA [2]Chemistry Department, Faculty of Science, Menoufia University, Shebin EI-Koam, Egypt [3]Collage of Science and Humanitles, Prince Sattam Bin Abdulaziz University, KSA [4]Faculty of Education for Girls, Prince Sattam Bin Abdulaziz University, KSA

出　　处：《Chemical Research in Chinese Universities》2016年第6期967-972,共6页高等学校化学研究（英文版）

摘　　要：Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′：4,5]thieno[3,2-d]pyrimidin-3（4H）-yl}acetohydrazide（5） with a variety of activereagents and chemicals. Structures of the newly synthesized compounds were established based on spectral data.The resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some ofthem represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayedthe highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in MIC range of 0.12--1.95 μg/mL.

关 键 词：Nitrogen-containing HETEROCYCLE Pyridothienopyrimidine Thieno[2 3-b]pyridine ANTIMICROBIAL 

分 类 号：O[理学]