面向近红外脑功能成像的光学自导引漫射光断层成像方法  

Optical Self-guiding Diffuse Optical Tomography towards Near-infrared Functional Brain Imaging

作　　者：赵会娟[1] 戚彩霞[1] 刘明[1] 秦转萍 张耀[1] 张丽敏[1] 李娇[1] 周仲兴[1] 高峰[1] ZHAO Hui-juan QI Cai-xia LIU Ming QIN Zhuan-ping ZHANG Yao ZHANG Li-min LI Jiao ZHOU Zhong-xing GAO Feng(College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China Tianjin Key Lab of Information Sensing ~Intelligent Control, Tianjin 300222, China)

机构地区：[1]天津大学精密仪器与光电子工程学院,天津300072 [2]天津市信息传感与智能控制重点实验室,天津300222

出　　处：《光子学报》2016年第11期1-9,共9页Acta Photonica Sinica

基　　金：国家自然科学基金(Nos.81371602;61475115;61475116;81401453;61575140;81571723;81671728);天津市自然科学基金(Nos.14JCQNJC14400;15JCZDJC31800;15JCQNJC14500;16JCZDJC31200);天津职业技术师范大学校科研发展基金(No.KYQD14007)资助~~

摘　　要：为降低近红外脑功能漫射光断层成像(DOT)固有的逆问题病态性,并避免多模态方法的图像配准等问题,提出了基于光学自导引提供先验功能信息的脑功能DOT方法(OT-DOT),并发展了图像重构方法.模拟验证表明:上皮厚度(TLT)已知时,OT-DOT获得的重构量化度(QR)约为传统DOT的4.2倍;当TLT的估计误差小于±10%时,OT-DOT重构的QR值可达92%以上,远远优于传统DOT;噪声鲁棒性测试表明,OT-DOT与传统DOT的噪声鲁棒性相近.利用连续光DOT测量系统的仿体实验重构结果表明,所发展的OT-DOT算法获得的重构结果优于传统DOT算法.The image reconstruction of diffuse optical tomography （DOT） for near-infrared brain functional imaging is a severely ill-posed inverse problem. Different from the widely adopted multi-mode imaging method for providing anatomical-prior to DOT, this paper proposed an optical self-guiding scheme, called OT-DOT, and the corresponding image reconstruciton algorithm is developed. The numerical and phantom validations are performed for the proposed method. Numerical reconstruction results indicate that quantitativeness ratio （QR） reconstructed with OT-DOT for the target is about 4.2 times bigger than that with traditional DOT for the known top layer thickness（TLT）. QR from OT-DOT can be more 92% when the estimation error of TLT is less than ± 10%. The noise-robustness testing indicates the reconstruction ability of OT-DOT and traditional DOT are roughly the same. Phantom experiments performed using a continuous-wave DOT system show that the reconstructed results with the proposed method is better than those with traditional DOT.

关 键 词：光谱学 生物医学光子学 光学自导引漫射光断层成像 脑功能 近红外 先验信息 图像重构方法 

分 类 号：Q63[生物学—生物物理学]