文拉法辛治疗轻型颅脑损伤后认知功能障碍的临床研究  

Therapeutic effects of venlafaxine on cognitive impairments following mild traumatic brain injury

作　　者：赵敏 刘湘衡[2] 王伟民[2] 王丽敏[2] 刘雁[3] Zhao Min Liu Xiangheng Wang Weimin Wang Limin Liu yan(Graduate School, Southern Medical University, Guangzhou, Guangdong 510515, China Department of Neurosurgery Department of Neurology, Guangzhou General Hospital of Guangzhou Command, Guangzhou, Guangdong 510010, China)

机构地区：[1]南方医科大学研究生学院,广州510515 [2]广州军区广州总医院神经外科,510010 [3]广州军区广州总医院神经内科,510010

出　　处：《中国微侵袭神经外科杂志》2016年第11期496-499,共4页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：全军"十二五"重大项目(编号:AWS12J004);国家自然科学基金(编号:81471172)

摘　　要：目的观察文拉法辛改善轻型颅脑损伤后(m TBI)病人认知功能障碍的有效性。方法 92例m TBI综合征病例,随机分为文拉法辛组(n=43)和安慰剂组(n=45)。文拉法辛组给予神经内科常规治疗及文拉法辛缓释剂(75mg/d,服药时间4周);安慰剂组仅给予神经内科常规治疗及安慰剂。在接诊时、治疗1个月及治疗3个月进行韦氏智力量表评估。结果两组认知功能评价指标随时间改善,其中故事记忆、图片记忆、理解、背数、触觉及韦氏智力总分指标,文拉法辛组改善比安慰剂组更快。治疗前后,两组自身对比及两组间对比,定向力均无显著性差异。两组联想评分随时间均改善,但两组间对比无显著差异。结论 m TBI综合征病人部分认知功能随时间推移逐步改善,文拉法辛缓释剂可明显促进m TBI病人认知功能,主要是记忆力和注意力功能恢复。Objective To explore the therapeutic effects of venlafaxine for cognitive impairments following mild traumatic brain injury（m TBI）. Methods Ninty-two cases of m TBI syndrome were randomly into venlafaxine group（n = 43） and placebo group（n = 45）. In addition to the general neurological treatments, patients in venlafaxine group were treated with venlafaxine 75 mg daily for 4 weeks,while patients in placebo group with only placebo. All participants accepted WAIS-III measurement at baseline, 1 month after and 3months after treatment. Results The cognitive functions were improved along with time after m TBI in both venlafaxine group and placebo group. Compared to placebo group, patients in venlafaxine group presented faster improvement in story memory, picture memory, understand, digit memory, tactile sense and WAIS-Ⅲ total score. Before and after treatment, there was no significant difference in the directional ability of the two groups. The association ability was improved with time, but there was no significant difference between the two groups. Conclusions The damage in cognitive function following the m TBI would relieve gradually along with time under the general neurological treatments. Venlafaxine may further improve the recovery from cognitive function impairment.

关 键 词：颅脑损伤 轻型 认知功能障碍 文拉法辛缓释剂 

分 类 号：R749.12[医药卫生—神经病学与精神病学]