高密度脂蛋白与脑动脉粥样硬化相关性研究  

Correlation study between high density lipoprotein -cholesterol with cerebral atherosclerosis

作　　者：刘勇[1] 陈胜利[1] 游曦[1] 熊见[1] Liu Yong Chen Shengli You Xi Xiong Jian(Department of Neurology, Chongqing Three Gorges Central Hospital, Chongqing 404000, Chin)

机构地区：[1]重庆三峡中心医院神经内科,重庆市404000

出　　处：《中国基层医药》2016年第24期3685-3687,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨高密度脂蛋白（HDL）与脑动脉粥样硬化（AS）的相关性。方法选择200例缺血性脑血管病患者，均于晨8：00空腹采集静脉血液检验血常规及生化指标，计算测量得到 HDL 占总胆固醇的比例，以25％为标准，≥25％为高 HDL 组，＜25％为低 HDL 组。同时进行双侧颈动脉超声检查，测量双颈总动脉内-中膜厚度，≥0．9 mm 为 AS 组、＜0．9 mm 为非 AS 组。结果经生化分析，200例患者中高 HDL 患者47例（高 HDL 组），低 HDL 患者153例（低 HDL 组）；高 HDL 组患者中经颈动脉多普勒超声检查确诊 AS 12例（25．53％）、非 AS 35例（74．47％），低 HDL 组患者中经颈动脉多普勒超声检查确诊 AS 139例（94．56％）、非 AS 14例（9．52％），低 HDL 组确诊 AS 患者显著高于高 HDL 组，HDL 占总胆固醇的比例与脑动脉粥样硬化呈负相关关系（r ＝－0．644，P ＜0．05）。结论 HDL 的检测对于脑动脉粥样硬化的诊断具有重要意义，可通过 HDL 含量评估缺血性脑血管病病情，为下一步治疗提供参考。Objective To explore the correlation between high density lipoprotein -cholesterol（HDL）with cerebral atherosclerosis（AS）.Methods 200 patients with potential cerebral AS were chosen.Blood routine and bio-chemical indices of venous blood of all patients were analyzed.According to the results of biochemical indices （25%）,all the patients were classified as high HDL group（≥25%）or low HDL group（〈25%）.According to the results of carotid artery ultrasonography by color Doppler flow imaging,all the patients were classified as AS group or non -AS group.Results According to the biochemical examination,there were 47 patients with high HDL（high HDL group）and 153 patients with low HDL（low HDL group）in all 200 cases with potential cerebral AS.There were 12 cases of AS（25.53%）and 35 cases of non -AS（74.47%）in the high HDL group,and there were 139 cases of AS（94.56%）and 14 cases of non -AS（9.52%）in the low HDL group,the final diagnosis rate of AS in the high HDL group was higher than that in the low HDL group,there was statistically negative correlation with AS（r =-0.644,P 〈0.05）.Conclusion Serum HDL levels bear a particular significance to the diagnosis of cerebral AS.

关 键 词：动脉粥样硬化 脑动脉 脂蛋白类 HDL 

分 类 号：R743[医药卫生—神经病学与精神病学]