加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃黏膜病理形态学的影响  

Influence of modified Qifang Weitong Granules on gastric mucosa in rats with chronic atrophic gastritis at the aspect of pathomorphology

作　　者：田惠芳[1] 唐梅文[1] 陈先翰 王鲜庭 全胜源 张为[1] 王婷[1] 

机构地区：[1]广西中医药大学,广西南宁530001 [2]南宁市中医医院,广西南宁530001

出　　处：《中国中西医结合消化杂志》2016年第11期839-841,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金资助项目(No:81260535)

摘　　要：[目的]观察加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃黏膜组织病理学改变的影响。[方法]将Wister健康大鼠120只按随机数字表法随机分成6组,20只空白组从一开始到取胃组织前均给予正常饮用水及食物,其余100只大鼠在饮用水中开始加入180μg/ml N-甲基-N’-硝基-N-亚硝基胍液(MNNG),饮用90d后,从第91天开始,除空白组外,其它五组分别给予生理盐水、胃复春、加味七方胃痛颗粒大、中、小剂量灌胃,灌胃30d后,禁食24h,剖取胃组织,沿胃小弯从前胃至幽门取全肌层壁2块,用10%甲醛固定,苏木精-伊红染色光镜观察。[结果]加味七方胃痛颗粒组和胃复春组均可以有效改善慢性萎缩性胃炎胃黏膜厚度、腺体萎缩,逆转肠化生及不典型增生。[结论]加味七方胃痛颗粒能明显改善慢性萎缩性胃炎大鼠受损胃黏膜组织的病理状况。[Objective]To observe the influence of modified Qifang Weitong Granules on pathology of gastric mucosa in the rats of chronic atrophic gastritis（CAG）.[Methods]120 Wister healthy rats were randomly divided into 6groups according to random number table method.The blank group were given healthy water and food from the beginning to take normal gastric tissue,while the remaining 100 rats were given water with 180 mu g/ml N-methyl-N＇-nitro-N-liquid nitrosoguanidine（MNNG）for 90 days.From the 91 st day,except the blank group,the rest 5groups were respectively given saline,Weifuchun and modified Qifang Weitong Granules of low,medium and high doses for 30 days.Then after fasting 24 h,the rats were sacrificed for collection of gastric mucosa tissue and observation of pathological changes.[Results]Both modified Qifang Weitong Granules and Weifuchun effectively improved the thickness,gland atrophy,reversal intestinalization and atypical hyperplasia of gastric mucosa in rats with CAG.[Conclusion]Modified Qifang Weitong Granules can significantly improve pathological changes of gastric mucosa impair in rats with chronic atrophic gastritis.

关 键 词：七方胃痛颗粒 慢性萎缩性胃炎 病理学 癌前病变 

分 类 号：R573.3[医药卫生—消化系统]