盐酸帕洛诺司琼胶囊与盐酸托烷司琼治疗乳腺癌术后辅助化疗引起呕吐疗效比较  

Palonosetron hydrochloride capsules and tropisetron hydrochloride in treatment of breast cancer postoperative adjuvant chemotherapy cause vomiting: curative effect comparison

作　　者：张琳琳[1] 白维君[1] ZHANG Lin-lin BAI Wei-jun(Fifth Department of Medical, China Medical University Cancer Hospital, Shenyang 110042, China)

机构地区：[1]中国医科大学肿瘤医院辽宁省肿瘤医院内五科,辽宁沈阳110042

出　　处：《临床军医杂志》2016年第11期1178-1180,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨盐酸帕洛诺司琼胶囊与盐酸托烷司琼在预防及治疗乳腺癌患者术后行环磷酰胺联合表柔比星方案(AC方案)辅助化疗引起的恶心、呕吐等消化道反应的疗效。方法选择2012年5月至2015年4月在沈阳军区总医院肿瘤科住院的确诊为三阴性乳腺癌术后患者36例为研究对象,统一采用AC方案化疗。将36例患者随机分为A、B两组,每组各18例。A组患者化疗前30 min使用盐酸帕洛诺司琼胶囊+阿瑞匹坦+地塞米松;B组患者使用盐酸托烷司琼+阿瑞匹坦+地塞米松,以防治恶心、呕吐。比较两组患者化疗后急性呕吐及延迟性呕吐的缓解率,并观察两组患者用药后头痛、便秘、眩晕等不良反应的发生率。结果 A组总有效率为94.4%,B组总有效率为77.8%,两组总有效率比较,差异无统计学意义(P>0.05)。但在急性呕吐期,A组的完全缓解率(83.3%)明显高于B组(50.0%),两组比较,差异有统计学意义(P<0.05);同时,延迟期呕吐的缓解率,A组的完全缓解率(44.4%)同样高于B组(11.1%),且两组比较,差异也有统计学意义(P<0.05)。在不良反应的比较中,A组便秘及胃肠道紊乱发生率低于B组,两组比较,差异有统计学意义(P<0.05)。结论盐酸帕洛诺司琼胶囊在化疗相关性呕吐的治疗中,疗效明显优于盐酸托烷司琼;其不良反应的发生率也明显低于盐酸托烷司琼。Objective To investigate the effect of palonosetron hydrochloride capsules and tropisetron hydrochloride in prevention and treatment of patients with breast cancer received cyclophosphamide combined with epirubicin scheme（ AC chemotherapy） adjuvant chemotherapy caused by gastrointestinal reactions such as nausea and vomiting. Methods A retrospective study was performed on36 patients with triple negative breast cancer（ TNBC）,patients were unified with AC chemotherapy in the General Hospital of Shenyang Military Command from May 2012 to April 2015. Patients were randomly divided into Group A and Group B,with 18 cases in each group. Patients in Group A were given palonosetron hydrochloride capsules ＋ aprepitant ＋ dexamethasone 30 minutes before chemotherapy. Patients in Group B were given tropisetron hydrochloride ＋ aprepitant ＋ dexamethasone 30 minutes before chemotherapy,to prevent nausea and vomiting. Comparing the two groups after chemotherapy in patients with acute vomiting and delayed vomiting response rate,and two groups of patients after headache,dizziness,constipation and the incidence of adverse reactions were observed. Results Total effective rate was in Group A and Group B was 94. 4% and 77. 8%,respectively,compared two groups of total effective rate,there was no statistically significant difference（ P 0. 05）. In acute vomiting period,the complete remission rate in Group A（ 83. 3%） was obviously higher than that in Group B（ 50. 0%）,the difference was statistically significant（ P 0. 05）. At the same time,delay vomiting response rate,the complete remission rate in Group A（ 44. 4%） was higher than that of Group B（ 11. 1%）,and the difference had statistical significance（ P 0. 05）. In the comparison of adverse reactions,the constipation and incidence of gastrointestinal disorders in Group A were lower than those in Group B,and the difference was statistically significant（ P 0. 05）. Conclusion Palonosetron hydrochloride capsules has more obvious advantage than tr

关 键 词：乳腺癌 盐酸帕洛诺司琼胶囊 盐酸托烷司琼 呕吐 

分 类 号：R737.9[医药卫生—肿瘤]