转录因子KLF4与肿瘤EMT的分子机制研究进展  

Research progress of molecular mechanism of transcription factor KLF4 and epithelial mesenchymal transition

作　　者：任晓丽[1] 陈丽君[1] 宋晖[1] 刘海霞[1] 陈必良[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032

出　　处：《中国妇幼健康研究》2016年第11期1426-1429,共4页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(项目编号:81301921);陕西省自然科学基金资助项目(项目编号:2013JM4023)

摘　　要：上皮间质转化(EMT)是一种在胚胎发育和损伤修复过程中的生理性改变,其是肿瘤发生和发展过程中的一种常见现象,但作用及机制尚不完全清楚。目前已经发现多个转录因子通过调控下游靶基因参与了EMT的发生过程,其中Krüppel样因子4(KLF4)能够活化上皮基因的表达,同时抑制间质基因的表达,在EMT发生过程中发挥着关键作用,可能是肿瘤治疗的新靶点。该文系统地总结了转录因子KLF4在肿瘤EMT发展过程中的作用及分子机制。Epithelial-to-mesenchymal transition （ EMT ） is a physiological change during embryonic development and injury repair process, and it is a common phenomenon in the process of occurrence and development of tumors .But its role and mechanism are still unclear.Currently, it has been found that several transcription factors are involved in EMT process through the regulation of downstream target genes.Among them, Kruppel like factor 4 （KLF4） can active the epithelial gene expression while inhibit stromal gene expression , which plays a key role in EMT genesis and may be the new target for tumor therapy .The aim of this review was to systematically summarize the role and molecular mechanism of transcription factor KLF 4 in the development of EMT in tumor .

关 键 词：转录因子KLF4 肿瘤 上皮间质转化 分子机制 

分 类 号：R730.26[医药卫生—肿瘤]