小胃肠间质瘤的临床病理学特征  

Clinicopathological features of small gastrointestinal stromal tumors

作　　者：崔力方[1] 张继新[2] 昌红[1] 赵洪禹 曲丛玲[1] 张建英[1] 沈兵[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院病理科,北京100038 [2]北京大学第一医院病理科,北京100034

出　　处：《临床与实验病理学杂志》2016年第12期1334-1337,1342,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 探讨小胃肠间质瘤（small gastrointestinal stromalt umors,sGIST）的临床病理学特征。方法 回顾性分析21例sGIST的临床病理学及免疫表型特征,对比分析非sGIST,并进行随访。结果 21例sGIST中女性7例,男性14例,中位年龄63岁,直径0.5-1.5cm,主要发生于胃,全部为梭形细胞型,其中9例同时伴有胃肠道恶性肿瘤。与非sGIST相比,sGIST很少出现肿瘤内出血、坏死、黏膜侵犯、溃疡及核分裂,复发风险明显低于非sGIST;免疫组化标记p53、Ki-67及肿瘤内微血管密度（microvascular density,MVD）明显低于非sGIST,差异有统计学意义（P〈0.05）。结论 sGIST可与胃肠道恶性肿瘤同时伴发,免疫组化标记p53、Ki-67及MVD均低于非sGIST,其预后较好。Purpose To assess the clinical and pathological features of small gastrointestinal stromal tumours （sGIST）. Methods To reevaluated the clinical, histological and immunohistochemical parameters of 21 sGISTs. The standard immunohistochemieal panel antibodies were studied on the tumor sections. All data were compared with clinical sGIST. Results There were a total of 7 females and 14 males of sGISTs. The median age was 63 years old. The tumors were predominantly located in the stomach showing a spindle cell morphology and the tumor sizes ranged from 0. 5 cm to 1.5 cm. 9 sGISTs combined with malignant tumors, which were gastric cancer have been incidentally detected during surgery. As the lesions were small in size, with infrequent bleeding, necrosis, mucosal invasion, ulceration and less mitotic index, sGISTs reoccurred less compared with clinical sGIST, p53, Ki-67 labeling index and microvascular density （MVD） in sGIST were significantly lower than clinical sGIST （P 〈 0.05 ）. Conclusion sGIST may occure with digestive tract cancer synchronously, p53, Ki-67 labeling index and MVD were lower than clinical GIST, which means better prognosis.

关 键 词：胃肿瘤 胃肠间质瘤 小胃肠间质瘤 微血管密度 预后 

分 类 号：R735[医药卫生—肿瘤]