少突胶质细胞瘤中FABP5的表达及其临床意义  

Expression of FABP5 and its clinic pathological significance in oligodendroglioma

作　　者：高婉婉 赵霞[1] 孟刚[1,2] 蔡莉[1,2] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022

出　　处：《临床与实验病理学杂志》2016年第12期1348-1352,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(81201052)

摘　　要：目的探讨脂肪酸结合蛋白5(fatty acid-binding protein 5,FABP5)在少突胶质细胞瘤中的表达及其临床意义。方法采用免疫组化En Vision两步法检测87例人脑少突胶质细胞瘤以及23例肿瘤旁脑组织中FABP5及Ki-67的表达。分析FABP5在少突胶质细胞瘤中的表达与Ki-67、临床病理参数以及预后的关系。结果 (1)FABP5在少突胶质细胞瘤中高表达率为63.2%(55/87),显著高于肿瘤旁脑组织(34.8%,8/23)(P<0.05);(2)FABP5在少突胶质细胞瘤中的表达与组织学分级(P=0.018,rs=0.254)、Ki-67表达呈正相关(P=0.003,rs=0.318);(3)单因素生存分析显示,FABP5蛋白、Ki-67、化疗、年龄与少突胶质细胞瘤患者预后相关(P<0.05)。结论 FABP5可能在少突胶质细胞瘤的发生、发展过程中发挥重要作用,有望成为判断少突胶质细胞瘤患者疾病进展及预后的生物学指标。Purpose To investigate the expression of FABP5 in oligodendroglioma and its clinic pathological significance. Methods Immunostaining of FABP5 and Ki-67 were performed in 87 oligodendrogliomas and 23 paracancerous brain tissues. The relationships between FABP5 expression and Ki-67 expression or clinic pathological parameters were statistically analyzed. Patients were followed up after operation. Results （ 1 ） The expression of FABP5 was significantly higher in oligodendroglioma [ 63.2% （55/87） ] than that in normal control [ 34. 8% （ 8/23 ） ]. （2） The expression of FABP5 was positively correlated with the histological grade （ P = 0. 018, r = 0. 254） and the Ki-67 expression（ P = 0. 003, r, = 0. 318 ）in oligodendroglioma. （3）Univariate analysis showed that the expression of FABP5 protein, Ki-67 protein, age and chemotherapy were significant prognostic factors for oligodendroglioma patients. Conclusion FABP5 may play an important role in the pathogenesis and progression of oligodendroglioma, and could be used as a novel biological in- dicator of disease progress as well as prognosis for oligodendroglioma patients.

关 键 词：脑肿瘤 少突胶质细胞瘤 脂肪酸结合蛋白5 KI-67 预后 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]