The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome  

光学比浊法和血栓弹力图法用于判断急性冠脉综合征患者氯吡格雷药物反应性的相关性和一致性对比研究（英文）

作　　者：聂小燕[1] 胥洋[2] 扶宇 李俊蕾[1] 梁广楷 张涌[3] 陆芸 刘健[3] 史录文[1] 

机构地区：[1]北京大学医学部药学院,北京100191 [2]北京大学医学部公共卫生学院,北京100191 [3]北京大学人民医院心血管内科,北京100044 [4]Hennepin County Medical Center,美国明尼苏达州55415

出　　处：《Journal of Chinese Pharmaceutical Sciences》2016年第11期838-845,共8页中国药学（英文版）

基　　金：Beijing Higher Education Young Elite Teacher Project(Grant No.YETP0064)from Beijing Municipal Education Commission

摘　　要：Various platelet function tests are currently used to identify responsiveness to antiplatelet therapy. 176 ACS patients were enrolled and Linear regression and Kappa consistency analysis showed there was a significant but moderate correlation between platelet inhibition rate and a significant but fair agreement between high clopidogrel on-treatment platelet reactivity tested by light transmission aggregometry and thrombelastography.本文连续纳入176例诊断为急性冠脉综合征且接受常规阿司匹林和氯吡格雷抗血小板治疗的患者,对比采用光学比浊法和血栓弹力图法检测氯吡格雷用药后血小板抑制率和血小板高反应性的相关性和一致性。结果发现两种方法检测血小板抑制率呈中等相关,检测确定的血小板高反应性呈中等程度一致性,未达到高度一致性要求。

关 键 词：Light transmission aggregometry THROMBELASTOGRAPHY CLOPIDOGREL High platelet reactivity CONSISTENCY 

分 类 号：R541.4[医药卫生—心血管疾病]