中期因子在结直肠癌患者外周血中的表达及其临床意义  

Expression and clinical significance of peripheral blood midkine in patients with colorectal cancer

作　　者：贾毅[1] 刘海义[2] 郭凯庆[1] 郭棕亮[1] 杨光[1] 郝振文[1] 王海波[1] 许奇[1] 

机构地区：[1]山西省肿瘤医院普外一科,太原030013 [2]山西省肿瘤医院结直肠肛门外科,太原030013

出　　处：《中国实用医刊》2016年第23期29-31,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨结直肠癌（CRC）患者外周血中的中期因子（MK）在诊断疾病和对结直肠癌预后判断方面的价值。方法选择2014年1月’至12月结直肠肛门外科126例结直肠癌患者为研究组，以75例健康体检者为对照组，分别检测两组外周血中MK蛋白以及癌胚抗原（CEA）的含量。两组样本分别采用成组t检验进行比较，多组样本采用方差分析方法及LSD-t检验方法进行比较。结果结直肠癌实验组较健康体检对照组外周血MK蛋白含量明显增高（P〈0．01）。Ⅰ＋Ⅱ期、Ⅲ期、Ⅳ期结直肠癌患者外周血中MK蛋白含量依次增高，分别为（431±88）、（498±71）、（600±78）pg／ml，对三者进行两两比较，差异均有统计学意义（P〈0．01）。在诊断结直肠癌方面，外周血MK蛋白的诊断价值要高于外周血CEA，通过计算二者ROC曲线下方面积分别为0．878和0．824，差异有统计学意义（P〈0．05）。结论外周血MK蛋白在诊断结直肠癌方面优于传统肿瘤标记物CEA。MK的升高也预示着结直肠癌患者较差的预后，表明外周血MK可能成为诊治结直肠癌的有效生物学标记物。Objective To investigate the value of peripheral blood midkine（MK） in the diagno-sis and prognosis of patients with colorectal cancer（CRC）. Methods A total of 126 patients with color- ectal cancer（ experiment group） and 75 healthy persons （control group） who underwent detection from January 2014 to December 2014 were selected. The levels of serum MK and carcinoembryonic antigen （CEA） were measured by ELISA. Group t-test, analysis of variance and LSD-t test were used to study the changes between the groups. Results The level of MK in the peripheral blood of experiment group was significantly higher than that of the control group （ P 〈 0. 01 ）. The levels of MK in stage Ⅰ＋ Ⅱ, stage Ⅲ,stage Ⅳ of CRC were （431±88）, （498±71）, （600±78） pg/ml, the differences were significant （P 〈0.01 ）. Moreover, the diagnostic value of MK protein in peripheral blood was higher than CEA and the area under the ROC curve was 0. 878 and 0. 824, the difference was significant （ P 〈 0. 05）. Conclusions The diagnosis value of peripheral MK protein in colorectal cancer is superior to conventional tumor markers CEA. The rise of peripheral MK protein indicates the poor prognosis of patients with colorectal cancer, suggesting that peripheral blood MK may be a valuable biomarker for diag-nosis and treatment of colorectal cancer.

关 键 词：结直肠癌 外周血 MK蛋白 癌胚抗原 

分 类 号：R735.34[医药卫生—肿瘤]