西吡氯铵含漱液治疗口腔念珠菌感染效果观察  

EFFECTS OF CETYLPYRIDINIUM CHLORIDE GARGLE ON ORAL CANDIDIASIS

作　　者：崔传江 胡松[2] 符大勇 

机构地区：[1]青岛市口腔医院修复科,山东青岛266001 [2]青岛大学附属医院老年医学科 [3]青岛市口腔医院牙体牙髓科

出　　处：《青岛大学医学院学报》2016年第5期604-606,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨西吡氯铵含漱液治疗口腔念珠菌感染的效果。方法 2013年7月—2015年7月,选取我科收治的87例确诊口腔念珠菌感染病人,随机分为观察组和对照组。两组分别给予西吡氯铵含漱液和聚维酮碘含漱液含漱,共治疗12周。比较两组治疗前后黏膜萎缩、红斑、疼痛评分及总体治疗效果。结果治疗后两组病人黏膜萎缩、红斑、疼痛评分均较治疗前明显降低,差异有统计学意义（t=3.69-6.33,P〈0.05）;治疗后观察组病人黏膜萎缩、红斑、疼痛评分均较对照组明显降低,差异有统计学意义（t=3.46-5.86,P〈0.05）;观察组疗效优于对照组,差异有统计学意义（u=4.33,P〈0.05）。结论西吡氯铵含漱液治疗口腔念珠菌感染,较聚维酮碘含漱液更有利于缓解口腔黏膜萎缩、红斑、疼痛,并能提高疗效,具有重要临床应用价值。Objective To assess the effectiveness of cetylpyridinium chloride gargle（CCG）in the treatment of oral candidiasis. Methods Eighty-seven patients with oral candidiasis,treated in Department of Stomatology during July 2013-July2015 period,were selected for this study.The patients were randomized to observation group and control group,CCG was given to patients in the observation group and those in the control group received povidone-iodine mouthwash.The course of treatment was two weeks.A comparison between the two groups was done in terms of mucosal atrophy,erythema,pain and overall treatment results. Results After treatment,the scores of mucosal atrophy,erythema and pain in patients of the two groups were significantly lower than that before treatment（t=3.69-6.33,P〈0.05）;the scores of mucosal atrophy,erythema and pain of the observation group were much lower than that of the control group（t=3.46-5.86,P〈0.05）.The curative effect of the observation group was better than that of control group（u=4.33,P〈0.05）. Conclusion Cetylpyridinium chloride gargle used for oral candidiasis is better than povidone-iodine mouthwash with regard to relieving oral mucosal atrophy,erythema,pain,and curative effect,which has important value in clinical application.

关 键 词：念珠菌病 口腔 西吡氯铵 漱口药 治疗结果 

分 类 号：R781.54[医药卫生—口腔医学] R988.2[医药卫生—临床医学]