苏拉明防治后囊膜混浊的实验研究  

Experimental research on the prevention and cure of posterior capsular opacification(pco) by suramin

作　　者：吴迪[1] 戈亚平[1] 王丹[1] 杜秋 辛浩蓉[1] 刘斌[1] WU Di GE Ya-ping WANG Dan DU Qiu XIN Hao-rong LIU Bin(Department of Ophthalmology of People＇s Hospital of Jilin Province, Jilin Changchun 130021, China Inuo Ophthalmology Hospital, Jilin Changchun 130000, China)

机构地区：[1]吉林省人民医院眼科,吉林长春130021 [2]吉林省长春一诺眼科医院,吉林长春130000

出　　处：《中国医刊》2016年第12期63-65,共3页Chinese Journal of Medicine

基　　金：吉林省卫生计生青年科研课题(2014Q010)

摘　　要：目的探讨苏拉明复合黏弹剂与肝素眼内灌注对大鼠后发性白内障的影响。方法选用健康大鼠制作白内障大鼠模型,行超声乳化白内障吸除术,术中分别应用普通黏弹剂、浓度为300μg/ml苏拉明复合黏弹剂及浓度为25μ/ml肝素,观察术后大鼠后囊膜混浊情况。结果浓度为300μg/ml苏拉明复合黏弹剂及浓度为25μ/ml肝素均能对鼠眼后发性白内障起到抑制作用,但苏拉明的作用更确切、疗效更好,长期效果更明显(P<0.05)。结论苏拉明复合黏弹剂较肝素能更好地预防鼠眼后发性白内障。Objective To investigate effect on rat posterior capsular opacification （PCO） from intraocular injections of suramin composite viscoelastic and heparin through animal experience.MethodWe choose healthy rats to make models of cataract and undergo phacoemulsification. General viscoelastic, suramin composite viscoelastic with 300 ug/ml concentration, and heparin with 25μ/ml concentration are applied separately in the operation. PCO of rats after operation is observed and analyzed.ResultSuramin composite viscoelastic with 300μg/ml concentration and heparin with 25μ/ml concentration have an inhibitive effect on PCO of rats’ eyes, and suramin has better curative effect and obvious long-term effect.ConclusionThis experience proves that suramin composite viscoelastic has better prevention of PCO of rat eyes than heparin.

关 键 词：苏拉明 肝素 后发性白内障 

分 类 号：R776.1[医药卫生—眼科]