zeste基因增强子同源物2高表达与雌激素受体阳性乳腺癌不良预后相关  

High enhancer of zeste homolog 2 correlates with poor prognosis of estrogen receptor - positive breast cancers

作　　者：张家铭[1] 许曦[3] 明小燕[2] 

机构地区：[1]武汉市中心医院甲乳外科,430014 [2]武汉市中心医院综合二科,430014 [3]江汉大学医学院,430056

出　　处：《中华实验外科杂志》2016年第12期2756-2758,共3页Chinese Journal of Experimental Surgery

摘　　要：目的观察表达不同水平组蛋白3第27位赖氨酸三甲基化（H3K27me3）、zeste基因增强子同源物2（EZH2）和x染色体重复转录三十四肽（UTX）的乳腺癌是否有不同的生物学特性。方法检测146例乳腺癌患者H3K27me3、EZH2和UTX的水平，探讨其对于乳腺癌预后判断的价值。结果H3K27me3过表达见于人表皮生长因子受体-2（Her-2）阴性病例。EZH2过表达则见于淋巴结转移、肿瘤直径〉20nlm以及有更高肿瘤分期和肿瘤分级的患者。运用COX比例风险回归模型研究结果显示，低H3K27me3和高EZH2在全体病例[风险比（HR）=2．57，95％可信区间（95％CI）：1．63-4．04，P〈0．01]以及ER阳性组（FIR=2．78，95％CI：1．52-5．09，P〈0．01）中均可作为独立预后因素。H3K27me3弱表达（HR=0．18，95％（51：0．07～0．49，P〈0．01）和EZH2高表达（HR=3．34，95％CI：1．20～9．27，P〈0．05）均与不良总生存期显著相关。UTX的表达与患者预后之间未见明显的联系，且H3K27me3的表达水平并不受EZH2／UTX的影响。结论检测ER阳性患者中，H3K27me3和EZH2的表达有助于判断乳腺癌的预后。Objective To observe the biological behaviors of breast cancer expressing defferent levels of histone 3 lysine 27 triple--methylation （ H3K27me3 ） , enhancer of zeste homolog 2 （EZH2） and ubiquitously transcribed tetratricopeptide repeat on chromosome X （UTX）. Methods The expression levels of H3K27me3, EZH2 and UTX in 146 cases of breast cancer were detected and their prognostic signifi cance was explored. Results H3K27me3 levels were higher in human epidermal growth factor reeeptor -2 （Her- 2） -negative samples. EZH2 expression was higher in breast cancers with lymph node metastasis, diameter 〉 20 ram, and have higher tumor grade and stage. Using a Cox regression model, H3K27me3 and EZH2 levels were independent prognostic factors for overall survival for all the breast cancers [ Hazard ratio （HR） = 2.57, 95% confidence interval （CI） ： 1.63 - 4.04, P〈 0.01 ] even the estrogen receptor （ER） - positive subgroup （ HR = 2. 78, 95% CI： 1.52 - 5.09, P 〈 0. 01 ） in our study. The combination of low H3K27me3 （ HR = 0. 18, 95% CI： 0. 07 - 0. 49, P 〈 0. 01 ） and high EZH2 （ HR = 3.34, 95% CI： 1.20 - 9.27, P 〈 0. 05 ） was significantly associated with worse survival. UTX level was not significantly as- sociated with prognosis and there were no correlations between H3K27me3 and EZH2/UTX expression. Con- clusion Low H3K27me3 and high EZH2 can be used as a prognostic factor for shorter overall survival for breast cancer, including the ER ＋ breast cancer subtype.

关 键 词：乳腺癌 组蛋白修饰 zeste基因增强子同源物2 预后 

分 类 号：R737.9[医药卫生—肿瘤]