女性非小细胞肺癌患者外周血性激素水平与癌组织雌激素受体表达的关系  

Serum levels of sex hormones and expression of estrogen receptors in female patients with non - small lung cancer

作　　者：卢珠明[1] 李民[1] 伍硕允[1] 周伟[2] 叶敏[1] 林志潮[1] 沈涛[1] 王正[3] 

机构地区：[1]江门市中心医院中山大学附属江门医院胸外科,529030 [2]江门市中心医院中山大学附属江门医院病理科,529030 [3]暨南大学第二临床医学院胸外科,深圳518020

出　　处：《中华实验外科杂志》2016年第12期2783-2785,共3页Chinese Journal of Experimental Surgery

基　　金：广东省科技计划项目（20128061700064）;江门市科技计划项目（2012-58）

摘　　要：目的观察女性非小细胞肺癌患者癌组织中雌激素受体（ER）表达与外周血性激素水平，探讨其相关性及其临床意义。方法应用磁性微粒分离的免疫酶联分析检测94例绝经前和128例绝经后女性非小细胞肺癌患者外周血性激素雌二醇（E2）、卵泡生成激素（FSH）、黄体生成激素（LH）、孕酮（P）水平，术后免疫组织化学法检测肿瘤标本中雌激素受体α（ERα）和B（ERβ）表达，分析其相互关系。结果绝经前94例女性非小细胞肺癌患者ERα无明显表达，ERβ表达阳性为36例，阳性率为38．29％；绝经后128例女性非小细胞肺癌患者ERα无明显表达，ERβ表达阳性为47例，阳性率为36．72％。绝经前女性非小细胞肺癌患者血清E2正常组79例患者中有54例ERβ无明显表达，25例等级表达；升高组15例患者中有4例ERβ无明显表达，11例等级表达。绝经前女性非小细胞肺癌患者血清E2正常组和升高组之间ERβ表达差异有统计学意义（P〈0．05）；FSH、LH正常组和升高组之间ERβ表达差异无统计学意义。P正常组和降低组ER表达差异无统计学意义（P〉0．05）；绝经后女性非小细胞肺癌患者血清P正常组中107例患者75例ERβ无明显表达，32例等级表达；降低组中21例患者6例ERβ无明显表达，15例等级表达。绝经后女性非小细胞肺癌患者血清P正常组和降低组ER表达差异有统计学意义（P〈0．05）；血清E2、FSH、LH正常组和升高组ER表达差异无统计学意义（P〉0．05）。结论女性非小细胞肺癌患者外周血存在性激素代谢的紊乱和失衡，绝经前雌激素异常可能影响ER表达，绝经后孕激素异常可能影响ER表达。Objective To investigate the relationship between the expression of estrogen receptor and serum sexal hormone level in female patients with non -small -cell lung carcinoma （NSCLC） and its significance. Methods The study subjects were 94 premenopausal women and 128 postmenopausal women with NSCLC. Serum levels of estradiol （ E2 ）, folliclestimulating hormone （ FSH）, luteinizing Hormone （LH） and progesterone （P） were measured by chemiluminescence and expression of ERα and ERβ was detected by immunohistochemistry. The relationship were analyzed. Results There was no expression of ERα in all female patients with NSCLC. Positive expression ERβ was present 36 patients in premenopausal women （38.29%） and 47 patients in promenopausal women （36. 72% ）. ERβwas not found in 54 cases of 79 premenopausal women with non - small cell lung in normal E2 group, while 25 cases showed grade expression. 4 cases of 15 patients had no obvious expression and 11 eases showed grade expression in hige- her E2 group. The expression of ERβ and serum levels of E2 between the normal group and the higher group in premenopausal women shows statistical significance （ P 〈 0.05 ）. No relationships were found ERβ and serum levels of FSH, LH between the normal group and the higher group in premenopausal women, se- rum levels of P between the normal group and the lower group, respectively （ P 〉 0. 05 ）. ERβ was notfound in 75 cases of 107 promenopausal women with non - small cell lung in normal P group, while 32 ca- ses showed grade expression. 6 cases of 21 patients had no obvious expression and 11 cases showed grade expression in lower P group. The expression of ERβ and serum levels of P between the normal group and the lower group in promenopausal women shows statistical significance （P 〈 0. 05）, No relationships were found ERβ and serum levels of E2, FSH, LH between the normal group and the higher group in promeno- pausal women （P 〉 0. 05）. Conclusion Serum levels of sex hormones have m

关 键 词：非小细胞肺癌 女性 性激素 雌激素受体 

分 类 号：R734.2[医药卫生—肿瘤]