Hp感染与胃炎、胃癌的相关性研究  

Research of correlation between Hp infection, gastritis and stomach cancer

作　　者：林静[1] 姚慧静[1] 

机构地区：[1]山东泰安市中心医院消化内科,271000

出　　处：《中国实用医药》2016年第31期25-26,共2页China Practical Medicine

摘　　要：目的探讨幽门螺杆菌（Hp）感染与胃炎、胃癌的关系，为胃癌的防治提供参考。方法选取150例慢性胃炎患者（慢性浅表性胃炎89例，慢性萎缩性胃炎61例），胃癌患者40例，对其均进行Hp检测及p53蛋白测定。结果男性阳性检出率（66．4％）明显高于女性（38．0％）（P〈0．05）。60-69岁Hp阳性检出率高于其他年龄段（P〈0.05）。胃癌患者Hp阳性检出率、p53阳性表达率高于其他胃病患者（P〈0．05）。Hp阳性感染患者p53阳性表达率明显高于Hp阴性患者（P〈0．05）。结论Hp感染与胃炎、胃癌的发生、进展密切相关，通过Hp感染的检测有利于胃癌的防治。Objective To investigate correlation between helicobacter pylori （Hp） infection, gastritis and stomach cancer, and to provide reference for prevention and treatment of stomach cancer. Methods There were 150 patients with chronic gastritis （89 chronic superficial gastritis cases and 61 chronic atrophic gastritis cases） and 40 patients with stomach cancer. All patients received Hp test and p53 protein detection. Results Mate cases had obviously higher positive detection rate （66.4%） than female cases （38.0%） （P〈0.05）. Patients aging 60-69 years old showed higher positive Hp detection rate than other age groups （P〈0.05）. Stomach cancer patients had higher positive Hp detection rate and positive p53 expression rate than patients with other gastropathy （P〈0.05）. Patients with positive Hp infection had higher positive p53 expression rate than those with negative Hp infection （P〈0.05）. Conclusion Hp infection is closely related with occurrence and progression of gastritis and stomach cancer. Detection of Hp infection is helpful for prevention and treatment of stomach cancer.

关 键 词：幽门螺杆菌感染 胃炎 胃癌 P53 

分 类 号：R573.3[医药卫生—消化系统] R735.2[医药卫生—内科学]