肠道菌群参与炎症性肠病发病机制研究新进展  

Role of intestinal microbiota in pathogenesis of inflammatory bowel disease

作　　者：张静之[1] 包春辉[2] 施征[2] 翁志军[2] 王晓梅[2] 吴璐一[1,3] 吴焕淦[2] 

机构地区：[1]上海中医药大学,上海市201203 [2]上海市针灸经络研究所,上海市200030 [3]上海市气功研究所,上海市200030

出　　处：《世界华人消化杂志》2016年第33期4505-4513,共9页World Chinese Journal of Digestology

基　　金：国家重点基础研究发展计划(973计划)基金资助项目;Nos.2009CB522900;2015CB554500;国家自然科学基金资助项目;No.81503656;81303033;81473758;上海高校高峰学科基金资助项目;上海市卫生局中医药科研基金资助项目;No.2014LQ065A;上海市教育委员会科研创新基金资助项目;No.2014YZ052~~

摘　　要：炎症性肠病(inflammatory bowel disease,I B D)是一种慢性反复发作的肠道炎症性疾病,其发病机制尚不明确.肠道菌群已被证实对肠道免疫系统的发育和激活具有重要作用,肠道菌群变化可能诱发或加重IBD,而调节肠道菌群对治疗IBD具有一定的积极作用,本文就目前肠道菌群与IBD之间关系的研究进展作一综述.Inflammatory bowel disease（IBD） is characterized by chronic non-specific inflammation of the intestinal tract,and it easily relapses.The pathogenesis of IBD is not fully clear up to now.Intestinal microbiota has been confirmed to play an important role in the development and activation of the intestinal immune system.The changes of intestinal microbiota may induce or aggravate IBD,and regulating intestinal microbiota may have positive effects on the treatment of IBD.This article will discuss the relationship between intestinal microbiota and IBD.

关 键 词：肠道菌群 炎症性肠病 微生态制剂 肠道菌群移植 

分 类 号：R574[医药卫生—消化系统]