MTA1、RECK在结肠息肉癌变过程中的表达及意义  

Significance of expression of MTA1 and RECK in carcinogenesis of colonic polyps

作　　者：陈现亮[1] 吴义娟[1] 吕卓[1] 赵慧敏[1] 韩宝娟[1] 

机构地区：[1]河北医科大学附属邢台人民医院消化内科,河北省邢台市054000

出　　处：《世界华人消化杂志》2016年第33期4514-4518,共5页World Chinese Journal of Digestology

基　　金：邢台市科技支撑计划基金资助项目;No.2014ZC157~~

摘　　要：目的研究MTA1、RECK在结肠息肉及结肠癌组织中的表达,探讨MTA1、RECK在结肠息肉癌变过程中的作用.方法应用免疫组织化学法检测结肠癌组织104例、结肠息肉组织114例,正常结肠黏膜组织30例中MTA1、RECK基因的表达.结果正常结肠组织、管状腺瘤、绒毛状腺瘤至结肠癌中MTA1阳性表达率呈逐渐上升趋势(P<0.05);结肠息肉(中重度异型增生)组中MTA1的阳性表达率高于结肠息肉(轻度异型增生)组(P<0.05);RECK在正常结肠组织、管状腺瘤、绒毛状腺瘤、结肠癌组中的表达率分别为100.00%、78.57%、77.27%、53.85%.正常结肠组织、管状腺瘤、绒毛状腺瘤至结肠癌中RECK阳性表达率呈逐渐下降趋势;中重度异型增生结肠息肉中RECK阳性表达率明显低于轻度异型增生结肠息肉,差异有统计学意义(P<0.05).结论结肠癌组织中MTA1呈高表达,RECK表达缺失.MTA1、RECK参与正常组织、癌前病变、癌组织的发生、发展,在结肠息肉的癌变过程中起着重要的作用.AIM To detect the expression of MTA1 and RECK in colonic polyps and colorectal carcinoma tissues,and to explore the role of MTA1 and RECK in the carcinogenesis of colonic polyps.METHODS Immunochemical staining was used to detect the expression of MTA1 and RECK proteins in 104 cases of colorectal carcinoma,114 cases of colonic polyps and 30 cases of normal colorectal mucosa.RESULTS The positive expression rate of MTA1 gradually increased from normal colorectal mucosa to tubular adenoma,villous adenoma and colorectal carcinoma（P〈0.05）.The positive expression rate of MTA1 in middle-severe dysplasia group was significantly higher than that in the mild dysplasia group in colonic polyps（P〈0.05）.The expression rates of RECK were 100.00%,78.57%,77.27%,and 53.85%in normal colonic tissue,tubular adenoma,villous adenoma and colon carcinoma,respectively.The positive expression rate of RECK gradually decreased from normal colonic tissues to tubular adenoma,villous adenoma and colon carcinoma.The expression rate of RECK in the severe dysplasia group was significantly lower than that in the mild dysplasia group in colonic polyps（P〈0.05）.CONCLUSION MTA1 is highly expressed in colorectal carcinoma,but the expression of RECK is absent.MTA1 and RECK may be involved in the carcinogenesis of colonic polyps.

关 键 词：MTA1 RECK 结肠息肉 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]