miR-30c在减轻肝细胞肝癌的侵袭与转移中的应用探讨  

Discussion on the Application of mi R-30c in Reducing the Invasion and Metastasis of Hepatocellular Carcinoma

作　　者：孙鹏[1] 宋远[1] 周晓晶[2] 

机构地区：[1]吉林省人民医院消化内科,吉林长春130021 [2]长春中医药大学基础医学院生物化学与分子生物学教研室,吉林长春130021

出　　处：《中国卫生标准管理》2016年第22期71-72,共2页China Health Standard Management

基　　金：吉林省卫生计生科研计划课题(20152084);吉林省卫生计生自筹经费课题(2015s2c06)

摘　　要：目的探讨mi R-30c在减轻肝细胞肝癌侵袭及转移中的应用价值。方法对肝癌及肝癌细胞系中的mi R-30c表达进行定量检测,分析对肝癌细胞侵袭的影响。结果有脉管转移组mi R-30c表达低于无脉管转移组;转染mi R-30c模拟物能对snail表达进行控制。结论 mi R-30c表达上调,可抑制snail表达,减轻侵袭。Objective To explore the application value of mi R-30 c in reducing the invasion and metastasis of hepatocellular carcinoma. Methods To detect the expression of mi R-30 c in hepatocellular carcinoma and hepatocellular carcinoma cell lines,and to analyze the role of the invasion of hepatocellular carcinoma cells. Results The expression of mi R-30 c was significantly lower than that of no vascular metastasis group,and the Snail expression was controlled by transfection of mi R-30 c. Conclusion mi R-30 c expression up regulation,can inhibit the expression of snail,reduce the invasion.

关 键 词：肝细胞肝癌 侵袭 转移 MI R-30c 

分 类 号：R735.7[医药卫生—肿瘤]