探析唐氏综合征孕产妇血清筛查的诊断意义  

The Diagnostic Significance of Serum Screening of Down's Syndrome in Pregnant Women

作　　者：范烨华 

机构地区：[1]江苏省南通市通州区妇幼保健所检验科,江苏南通226300

出　　处：《中国卫生标准管理》2016年第23期145-147,共3页China Health Standard Management

摘　　要：目的 分析唐氏综合征孕产妇血清筛查的诊断价值。方法 选择2014年1~6月来我所门诊进行产前筛查的孕中期孕妇433例,对其血清AFP、β-HCG、游离雌三醇（Ue3）浓度进行检测,根据孕妇的妊娠胎数、年龄、体重和孕周来对唐氏综合征风险值进行计算。结果 经筛查,全部433例孕妇中,共有43例唐氏综合征高危患者,羊水染色体复查,有6例染色体异常,包括2例18-三体,3例21-三体,1例47XXY,均给予引产术中断妊娠。结论 测定中晚期孕妇的血清AFP、β-HCG、Ue3值,是无创性检测方式,对于筛查唐氏综合征胎儿具有非常重要的作用。Objective To analyze the diagnostic value of maternal serum screening for down syndrome. Methods Chose 433 cases of second trimester pregnant wonaen for prenatal screening from January to June 2014 in our clinic, the serum AFP, beta-HCG, free female three alcohol （ Ue3 ） concentration were detected according to the nmnber of pregnant women, pregnaucy, age, weight and gestational weeks of down syndrome risk calculated resnlts. Results Screening of all 433 cases, there were 43 cases of down syndrome in high-risk patients, 6 cases were amniotic fluid chronmsome, chromosomal abnormalities, including 2 cases of trisomy 18-trisomy, 3 cases of 21-trisomy, 1 cases of 47XXY were given abortion interruption of pregnancy. Conclusion The levels of AEP, the conclusion in the determination of pregnant women in late beta-HCG, Ue3 value that is a noninvasive detection inethod, plays a very important role in screening for down syndrome fetuses.

关 键 词：唐氏综合征 孕产妇 血清筛查 诊断价值 

分 类 号：R446[医药卫生—诊断学]