中药石连饮对肥胖大鼠下丘脑外侧区(LHA)神经细胞自发放电的影响  

Effects of Shilianyin on Spontaneous Discharges of Neurons in the Lateral Hypothalamic Area (LHA) in Obese Rats

作　　者：韩海荣[1] 王国芳[2] 刘德全[3] 

机构地区：[1]郑州大学附属洛阳中心医院教学办,河南洛阳471000 [2]山东省济宁医学院药理学教研室,山东济宁272069 [3]郑州大学附属洛阳中心医院神经内三区,河南洛阳471000

出　　处：《中国卫生标准管理》2016年第23期181-182,共2页China Health Standard Management

基　　金：山东省教育厅项目(课题名称:石连饮抑制食欲作用的机理研究;课题编号:J06L58)

摘　　要：目的探讨中药石连饮对肥胖大鼠下丘脑外侧区(LHA)神经细胞自发放电的影响。方法采用神经细胞微电极记录肥胖组和正常组大鼠LHA神经细胞自发放电情况;将肥胖组大鼠随机分为石连饮组和纯净水组,观察其LHA神经细胞自发放电情况。结果肥胖组LHA神经细胞自发放电频率高于对照组(P<0.05),石连饮组低于纯净水组(P<0.05)。结论中药石连饮能有效降低肥胖大鼠LHA神经细胞自发放电的频率。Objective To investigate the effects of traditional Chinese medicine （ TCM ） shilianyin on spontaneous discharges of neurons in the lateral hypothalamic area （ LHA ） in obese rats. Methods The obese rats were randomly divided into shilianyin group and pure water group, to observe the neuronal spontaneous discharge in LHA situation. Results The frequency of spontaneous discharge of LHA nerve cells in pure water group was significantly higher than shilianyin group （P 〈 0.05 ）, and the shilianyin group was significantly lower than that of pure water group （P 〈 0.05 ） . Conclusion The frequency of spontaneous discharge of LHA neurons in obese rats could be decreased by the shilianyin.

关 键 词：石连饮 下丘脑 自发放电 

分 类 号：R-33[医药卫生]