重庆市女性HPV感染情况的流行病学调查  

Epidemiological investigation of HPV infection of the females in Chongqing city

作　　者：孙聪聪[1] 梁爽[2] 蒋鹏[3] 胥飚[4] 王佳[1] 

机构地区：[1]重庆医科大学附属大学城医院妇产科,401331 [2]重庆市妇幼保健院检验科,404000 [3]重庆医科大学附属第三医院(捷尔医院)内分泌疾病中心,401120 [4]重庆医科大学附属第一医院检验科,400016

出　　处：《重庆医学》2016年第36期5136-5138,共3页Chongqing medicine

基　　金：重庆市科委资助项目(CSTC2010BB5331);重庆市卫生和计划生育委员会资助项目(20141014);重庆市妇科微创诊治特色专科项目(渝卫科教2013[46]号)

摘　　要：目的调查重庆市女性群体人乳头瘤病毒（HPV）的感染情况，为预防HPV的感染及早期宫颈病变的防治提供科学依据。方法收集2012年1月至2015年1月重庆医科大学附属大学城医院、重庆医科大学附属第一医院及重庆市某县级医院门诊、住院的19860例妇产科患者的宫颈细胞学检查结果，并分析其HPV分型。结果19860例研究对象中，HPV阳性5681例，感染率为28．61％。由于研究对象存在多重感染，故5681例感染人群中实际HPV亚型感染频数为8906，而高危型感染频数为6166（包含多重感染），占总感染频数的构成比为69．23％。将感染亚型分别按感染概率高低排序，排在前8住的是：52型、16型、58型、6型、CP8304（81型）、33型、53型、18型。HPV单一感染阳性率为19．38％，多重感染率为8．74％，其中多重感染以二重感染为主。研究人群中小于或等于20岁组感染率最高（43．89％），36～50岁组感染率最低（27．26％）。结论重庆市女性HPV感染率高，且以高危型感染为主，HPV52、16、58、33、18型为重庆市女性HPV感染预防的重点。Objective To investigate the infection status of human papillomavirus（HPV） of females in Chongqing city,in order to provide scientific references for prevention of HPV infection and control of early cervical lesions. Methods The detection results of cervical cytology screening for 19 860 females in the University-Town Hospital of Chongqing Medical University,the First Affiliated Hospital of Chongqing Medical University and a county-level hospital in Chongqing from January 2012 to January 2015 were collected,and the HPV typing data were analysed. Results Among the 19 860 females, 5 681 females were infected with HPV,the infection rate was 28.61%. Due to the presence of multiple infection, the actual infection frequency of HPV subtypes in 5 681 females was 8 906. The infection frequency of high-risk subtypes, including multiple infections, was 6 166 （accounted for 69.23% ）. According to the probability of infection,the top eight rate of subtype infection was HPV 52,16,58,6, CP8304 （81）, 33, 53 and 18. The positive rate of single HPV infection was 19.38% ,the positive rate of multiple infection was 8.74% ,in which double infection was the main infection model. The infection rate of females aged 20 years old or less（43.89%） was the highest, while have the infection rate of females aged 36-50 years old was thelowest（27.26%）. Conclusion The HPV infection rate of females in Chongqing is high,the most of females infected by high-risk subtype HPV. It is necessary to lay emphasis on preventing HPV52, 16,58,33,18 infection for females in Chongqing city.

关 键 词：人乳头瘤病毒 流行病学方法 重庆 

分 类 号：R737.33[医药卫生—肿瘤]