重组人干扰素对提高宫颈癌术后放疗患者性生活质量的价值初探  

Value exploration of recombinant human interferon to increase the quality of sex life of cervical cancer patients after radiotherapy

作　　者：吴发伟[1] 王小特[2] 冯蕾[3] WU Fawei WANG Xiaote FENG Lei(Department of Oncology, The 323 Hospital of People＇ s Liberation Army, Xi＇ an 710054, Shaanxi, China Department of Obstetrics and Gynecology, The 323 Hospital of People＇s Liberation Army, Xi＇ an 710054, Shaanxi, China Department of Basics, The Fourth Military Medical University, Xi＇ an 710054, Shaanxi, China)

机构地区：[1]解放军第323医院肿瘤科,西安710054 [2]解放军第323医院妇产科,西安710054 [3]第四军医大学基础部,西安710054

出　　处：《中国性科学》2016年第12期59-62,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨重组人干扰素对提高宫颈癌术后放疗患者性生活质量的临床价值。方法:选择2011年4月至2015年6月本院收治的宫颈癌术后实施规律放射治疗患者80例,按照随机数字法分为两组,各40例,术后对照组联合放射治疗,观察组则在对照组基础上使用重组人干扰素α-2b栓,对所有患者随访6个月,比较两组恢复性生活时间、性唤起时间、每月性生活频率,两组干预前后焦虑及抑郁评分,两组干预后FSFI评分情况及干预过程中免疫球蛋白变化情况。结果:观察组恢复正常性生活时间显著早于对照组(P<0.05),进行性生活时性唤起时间显著快于对照组(P<0.05),每月性生活次数显著多于对照组(P<0.05),干预后两组焦虑及抑郁评分均显著低于干预前(P<0.05),干预后,观察组焦虑及抑郁评分均低于对照组(P<0.05),观察组干预后患者女性FSFI评分中性欲、性唤起、性高潮及性心理得分均显著高于对照组(P<0.05),干预后,两组Ig M、Ig G和Ig A水平均显著低于干预前(P<0.05),且观察组Ig M、Ig G和Ig A水平显著低于干预后对照组(P<0.05)。结论:重组人干扰素对提高宫颈癌术后放疗患者性生活质量,促进早日恢复正常性生活,缓解患者不良心理状态,提高免疫能力有积极意义。Objectives： To investigate the clinical value of recombinant human interferon to increase the quality of sex life of patients after radiotherapy. Methods： 80 cervical cancer patients received radiation therapy in our hospital from April 2011 to June 2015 were selected and randomly divided into two groups,with 40 cases in each group. Control group received postoperative radiotherapy,and observation group received postoperative radiotherapy combined recombinant human interferon α- 2b suppository. All patients were followed up for 6 months. Restorative time of life,arousal time and the monthly frequency of sexual activity of two groups were compared. Anxiety and depression scores before and after the intervention,circumstances FSFI score after the intervention and immunoglobulin changes during the intervention were observed. Results： Recovery of normal sexual life in the observation group was significantly earlier than that of control group（ P〈0. 05）,while sexual arousal life time of observation group was significantly faster than that of control group（ P〈0. 05）. The monthly time of sex life of observation group was significantly more than that of control group（ P〈0. 05）. Anxiety and depression scores of the two groups after the intervention were significantly lower than these before intervention（ P〈0. 05）. After the intervention,anxiety and depression score of observation group was lower than that of control group（ P〈0. 05）. After the intervention,sex desire,arousal,orgasm and psychological scores in FSFI scores of female patients in observation group were significantly higher（ P〈0. 05）. After intervention,Ig M,Ig G and Ig A levels of both groups were significantly lower than these before the intervention（ P〈0. 05）,and Ig M,Ig G and Ig A levels of observation group were significantly lower than these of control group after the intervention（ P〈0. 05）. Conclusion： The recombinant human interferon canimprove the quality of sex life of patients with cervical canc

关 键 词：重组人干扰素 宫颈癌 术后放疗 性生活质量 

分 类 号：R737.33[医药卫生—肿瘤]