男性缺陷型与非缺陷型精神分裂症患者血清睾酮、催乳素和社会功能比较研究  

Comparison of serum testosterone,serum prolactin and social function between patients with deficit schizophrenia and patients with non-deficit schizophrenia

作　　者：赵小亚[1] 唐小伟[1] 肖文焕[1] 李金[1] 刘进文[1] 张晓斌[1] 沙维伟[1] 

机构地区：[1]扬州大学医学院附属五台山医院,江苏扬州225003

出　　处：《实用临床医药杂志》2016年第23期20-22,35,共4页Journal of Clinical Medicine in Practice

基　　金：2015年度江苏省卫生和计划生育委员会指导性科研课题(Z201522);江苏省扬州市科技发展计划-社会发展项目(YZ2014215)

摘　　要：目的探讨缺陷型精神分裂症(DS)与非缺陷型精神分裂症(NDS)患者血清睾酮、血清催乳素和社会功能状况。方法纳入相匹配的DS患者35例和NDS患者33例,采用电化学发光免疫分析技术检测血清睾酮、催乳素水平。使用简明精神病评定量表(BPRS)、阴性症状量表(SANS)、阳性症状量(SAPS)评估临床症状,使用社会适应功能评估量表(SAFE)评估社会功能。结果 DS患者的BPRS阴性症状分、BPRS总分、SANS分显著高于NDS患者(P<0.001)。DS患者SAFE与年龄、病程、BPRS阴性症状分、SANS分呈正相关(r=0.396,P=0.019;r=0.553,P<0.001;r=0.339,P=0.046;r=0.414,P=0.013),与BPRS情感症状分呈负相关(r=-0.454,P=0.006)。线性回归分析发现SAFE与病程(β=0.417,P=0.005)、SANS(β=0.398,P=0.008)相关联。NDS患者SAFE与年龄、病程呈正相关(r=0.503,P=0.003;r=0.350,P=0.046)。线性回归分析发现SAFE仅与年龄相关联(β=0.396,P=0.023)。结论 DS患者存在明显的高催乳素状态,社会功能受损严重,而原发性阴性症状可能明显影响DS患者的社会功能恢复。Objective To investigate the levels of serum testosterone, serum prolactin and social function in patients with deficit schizophrenia and patients with non-deficit schizophrenia. Methods The serum testosterone and prolactin levels were detected in 35 patients with DS and 33 patients with NDS by the electro chemiluminescence immunoassay technique. The Brief Psychiatric Rating Scale （BPRS）, Scale for the Assessment of Negative Symptoms （SANS）, Scale for the As- sessment of Positive Symptoms （SAPS） were used to assess the clinical symptoms, and social-adap- tive functioning evaluation （SAFE） was used to evaluate social function. Results Defective Nega- tive symptom score of BPRS, total BPRS score and SANS score in patients with DS were significantly higher than those in patients with NDS （P 〈 0.01 ）. In DS patients, SAFE was positively correlated with age, duration of disease, BPRS negative symptoms, SANS score （r = 0. 396, P = 0. 019 ; r = 0. 553, P 〈0. 001 ; r = 0. 339, P = 0. 046 ; r = 0. 414, P = 0. 013 ）, and was negatively correlated with BPRS emotional symptoms （ r = - 0. 454, P = 0. 006 ）. Linear regression analysis revealed that SAFE was associated with the course of disease （β =0. 417, P =0. 005） and SANS （β =0. 398, P = 0. 008）. In NDS patients, SAFE was positively correlated with age, duration of disease （r = 0. 503,P = 0. 003 ; r = O. 350, P = 0. 046）. Linear regression with age （β = 0. 396, P = 0. 023）. Conclusion In status, and the social function is severely impaired, cantly affect the recovery of social function. analysis revealed that SAFE was only associated DS patients, there is an obvious high prolactin and the primary negative symptoms can signifi-cantly affect the recovery of social function.

关 键 词：缺陷型精神分裂症 睾酮 催乳素 社会功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]