CCL2/MCP-1在其相关疾病的机制研究  

Mechanism of CCL2 / MCP-1 in its relevant diseases

作　　者：姜懿纳 陈乃宏[1,2] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国药理学通报》2016年第12期1634-1638,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81373997);北京市自然科学基金资助项目(No 7131013)

摘　　要：趋化因子(chemokine)是一类在人体的生理机能中发挥着重要作用的小分子蛋白,多由免疫细胞和神经胶质细胞等分泌,具有化学趋化活性。CCL2是趋化因子CC亚家族(又称β亚家族)成员之一,即单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1),可以趋化单核细胞、巨噬细胞和T淋巴细胞,影响其吞噬作用以及产生抗体,从而对抗外来入侵微生物的生理功能。由于CCL2作用广泛,在体内各个部位均有一定表达,因此在近年来的研究中发现CCL2在肿瘤、中枢神经系统疾病、免疫系统疾病、艾滋病、白血病、糖尿病等诸多疾病的发生发展中起到了关键性的作用,该文就CCL2及其相关疾病的最新研究展开综述。Chemokine is a small protein which plays an important role in men＇s physiological function. It has chemotactic activity and is often secreted by immune cells and glial cells like microglia or astrocytes. Through the effect of chemokine receptors on target cells,various immune cells can achieve directional migration and play an important role in the diseases related with immunity and inflammation. CCL2,also known as monocyte chemotactic protein-1（ MCP-1）,is one member of chemokine CC subfamily（ β subfamily）. It can chemokine monocytes,macrophages and T lymphocytes to affect their phagocytosis function and produce antibodies to combat invading microorganisms.In recent years,it has been found that CCL2 plays a key role in the occurrence and development of the problems concerning central nervous system and immune system as well as cancer,AIDS,leukemia,diabetes and other diseases. This thesis is to give an elaboration on the latest research on CCL2 and the relevant diseases.

关 键 词：趋化因子 CCL2 受体 单核细胞 免疫系统 肿瘤 神经疾病 

分 类 号：R-05[医药卫生] R392.11