姜黄益智胶囊治疗血管性痴呆临床研究  

Clinical observation of Jianghuang-yizhi capsule on the treatment of vascular dementia

作　　者：吴兵兵[1] 周德生[2] 廖端芳[3] 郭纯[3] 黄莹[4] 邓龙[1] 

机构地区：[1]湖南中医药大学 [2]湖南中医药大学第一附属医院脑病一科,湖南长沙410007 [3]湖南中医药大学药学院,湖南长沙410208 [4]湖南中医药大学第一附属医院脑病二科,湖南长沙410007

出　　处：《河北中医》2016年第10期1479-1483,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：湖南中医药大学2015年度干细胞中药调控与应用实验室开放基金资助项目(编号:2015GXB01)

摘　　要：目的观察姜黄益智胶囊治疗血管性痴呆(VD)的临床疗效和安全性。方法将72例VD患者随机分为2组,对照组予基础药物+尼麦角林片治疗,治疗组予基础药物治疗+姜黄益智胶囊治疗,疗程3个月。观察治疗前、治疗后1、3个月进行中医证候疗效积分、简易精神状态量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)评分及安全性评价。比较2组治疗前后局部脑血流量(rCBF)变化情况。结果治疗组中医证候总有效率83.9%,高于对照组(64.5%,P<0.01)。2组治疗1、3个月后MMSE评分均升高,NIHSS评分均降低(P<0.05,P<0.01)。治疗组治疗1、3个月后MMSE及NIHSS评分改善情况均优于对照组(P<0.05,P<0.01)。2组治疗后rCBF较治疗前均升高(P<0.05,P<0.01);治疗组治疗后rCBF高于对照组(P<0.05)。2组治疗期间均未出现不良反应。结论姜黄益智胶囊能更有效地治疗VD,改善患者神经功能缺损及局部脑血流灌注,促进神经功能恢复,且不良反应少,安全性佳。Objective To observe the clinical effects and safety of Jianghuang-yizhi capsule on the treatment of vascular dementia（VD）. Methods 72 VD patients were randomly divided into two groups. The control group received primary drug and nicergoline tablets,the treatment group received primary drug and Jianghuang-yizhi capsule,continuously treatment for three months. The traditional Chinese medicine（TCM） syndrome effects,mini-mental state examination（MMSE）,national institute of health stroke scale（NIHSS） and the safety evaluation were observed at before,1 and 3 months of treatment. The regional cerebral blood flow（rCBF） before and after treatment were compared between two groups. Results The total effective rate of TCM syndrome after treatment in treatment group（83. 9%） was higher than control group（64. 5%,P〈0.01）. The MMSE after 1 and 3 months were increased in two groups,the NIHSS was decreased（P〈0.05,P〈0.01）. The improvements of MMSE and NIHSS after 1 and 3 months in treatment group were better than those in control group（P〈0.05,P〈0.01）. The rCBF after treatment was increased in two groups（P〈0.05,P〈0.01）. The rCBF after treatment in treatment group was higher than control group（P〈0.05,）. There were no adverse reaction during treatment. Conclusion Jianghuang-yizhi capsule has more effective effects on VD,can improve neurologic impairment and regional cerebral blood flow then to promote neural function,with fewer adverse reaction and high safety.

关 键 词：姜黄 益智 痴呆 血管性 中药疗法 

分 类 号：R743.905.8[医药卫生—神经病学与精神病学]