中药补肾养血方联合激素替代法对卵巢早衰患者性激素水平及症状评分的影响  

Effect of Bushen Yangxue decoction combined with hormone replacement on sex hormone level and symptom score with premature ovarian failure

作　　者：阮凡[1] 石吟[1] 李丽洁[1] RUAN FanA SHI Yin LI Li-jie(Department of Gynecology and Obstetrics, Zhejiang Tongde Hospital, Hangzhou 310012, China)

机构地区：[1]浙江省立同德医院妇产科,浙江杭州310012

出　　处：《中国生化药物杂志》2016年第12期118-120,123,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨补肾养血方联合激素替代法对卵巢早衰患者性激素水平及症状评分的影响。方法选取2014年3月~2015年11月浙江省立同德医院将112例卵巢早衰患者分为对照组与联合组,每组56例。对照组采用激素替代法治疗,联合组在对照组基础上给予补肾养血方治疗。对比2组治疗结束时疗效,于治疗前、治疗结束时、停药3个月后,对比2组性激素、中医症状评分、生存质量测定量表（QOL）评分、子宫内膜厚度变化情况。结果治疗结束时,联合组的总有效率（91.07%）与对照组的（85.71%）比较无显著差异;2组治疗结束时中医症状评分、QOL评分显著降低,子宫内膜厚度显著升高（P〈0.05）;与对照组治疗结束时比较,联合组中医症状评分较低（P〈0.05）,QOL评分与子宫内膜厚度比较无显著差异;停药3个月后,联合组中医症状评分、QOL评分与治疗结束时的水平比较无显著差异,子宫内膜厚度降低（P〈0.05）;对照组中医症状评分、QOL评分显著升高,且显著高于联合组同期的水平,子宫内膜厚度显著降低,且显著低于联合组同期的水平（P〈0.05）;治疗结束时,2组黄体生成素（luteinizing hormone,LH）、促性腺激素（follicle-stimulatinghormone,FSH）显著降低,雌激素（estradiol,E_2）显著升高（P〈0.05）;治疗结束时2组间对比无显著差异;停药3个月后,联合组E2、LH、FSH与治疗结束时的水平对比无显著差异;对照组与治疗结束时相比,停药3个月后对照组LH、FSH水平较低,E2水平较高（P〈0.05）,与对照组比较,联合组停药3个月后LH、FSH水平较低,E2水平较高（P〈0.05）。结论补肾养血方联合激素替代法能显著提高卵巢早衰患者性激素水平,促使患者卵巢功能恢复。Objective To investigate the effects of Bushen Yangxue decoction combined with hormone replacement effects on sex hormone level and symptom score in patients with premature ovarian failure. Methods 112 patients with premature ovarian failure from March 2014 to November 2015 in Zhejiang Tongde Hospital were divided into two groups with 56 cases in each group. The control group was treated with hormone replacement therapy,the combined group was treated with Bushen Yangxue decoction on the basis of the control group. The curative effect was compared between the two groups,the sex hormone,traditional Chinese medicine symptoms score,QOL score and endometrial thickness were compared between the two groups before treatment,at the end of treatment and 3 months after discontinuation. Results At the end of the treatment,there was no significant difference in total effective rate between the combined group（ 91. 07%） and the control group（ 85. 71%）. At the end of the treatment,the scores of TCM symptoms and QOL scores were significantly lower in the two groups,and the endometrial thickness was significantly higher（ P〈0. 05）,compared with the control group at the end of treatment,the combined group TCM symptom score was lower（ P〈0. 05）,QOL score and endometrial thickness had no significant difference,after stopping drug for three months,there was no significant difference in the levels of TCM score,QOL score,endometrial thickness between the two groups. In the control group TCM score,QOL score were significantly higher,and significantly higher than the levels of the same period of the combined group,endometrial thickness was significantly lower,and the level of the same period was significantly lower than that of the combined group（ P〈0. 05）,at the end of treatment,the two groups of FSH,LH significantly decreased,E_2 significantly increased（ P〈0. 05）,there was no significant difference between the two groups,after stopping drug for three months,there was no significant difference in the levels

关 键 词：补肾养血方 激素替代法 卵巢早衰 性激素 E2 LH FSH 

分 类 号：R743[医药卫生—神经病学与精神病学]