17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107  

17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107

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作  者:LIU Meng-Yu-Jie LI Shan-Ren LU Chun-Hua 

机构地区:[1]Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University

出  处:《Chinese Journal of Natural Medicines》2016年第12期931-933,共3页中国天然药物(英文版)

基  金:supported in part by National Basic Research Programs of China(No.2012CB721005);the Natural Science Foundation of Shandong Province Youth Project(No.ZR2013 HQ048);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT13028)

摘  要:A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester(1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data(~1H NMR, ^(13) C NMR, ~1H-~1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester(1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data(~1H NMR, ^(13) C NMR, ~1H-~1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.

关 键 词:17-[16 17-Dihydroxycyclooctatinyl]-hexaketide ester Streptomyces sp. SR107 DITERPENES Antibacterial activity 

分 类 号:R284.1[医药卫生—中药学]

 

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