17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107  

作　　者：LIU Meng-Yu-Jie LI Shan-Ren LU Chun-Hua 

机构地区：[1]Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University

出　　处：《Chinese Journal of Natural Medicines》2016年第12期931-933,共3页中国天然药物（英文版）

基　　金：supported in part by National Basic Research Programs of China(No.2012CB721005);the Natural Science Foundation of Shandong Province Youth Project(No.ZR2013 HQ048);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT13028)

摘　　要：A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester(1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data(~1H NMR, ^(13) C NMR, ~1H-~1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester（1）, a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data（~1H NMR, ^（13） C NMR, ~1H-~1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS）. The antibacterial activity was also evaluated in this paper.

关 键 词：17-[16 17-Dihydroxycyclooctatinyl]-hexaketide ester Streptomyces sp. SR107 DITERPENES Antibacterial activity 

分 类 号：R284.1[医药卫生—中药学]