DITERPENES

作品数：51被引量：82H指数：5
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相关领域：医药卫生理学更多>>
相关作者：王辉王保怀曾慧慧屠鹏飞卢景芬更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Pharmaceutical Analysis》《Journal of Life Sciences》《Journal of Integrative Medicine》《Natural Products and Bioprospecting》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市青年科技启明星计划更多>>
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Polyoxygenated cembrane-type diterpenes from the Hainan soft coral Lobophytum crassum as a promising source of anticancer agents with ErbB3 and ROR1 inhibitory potential
《Acta Pharmacologica Sinica》2025年第1期196-207,共12页Shou-mao Shen Dan-dan Yu Lin-mao Ke Li-gong Yao Ming-Zhi Su Yue-wei Guo 
This research was financially supported by the National Natural Science Foundation of China(Nos.22167010 and 81991521);the National Key Research and Development Program of China(No.2022YFC2804100);the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.23KJB350011);the Shandong Laboratory Program(SYS202205);the Basic Research Project of Guizhou University(No.2023-51).
A detailed chemical investigation of the Hainan soft coral Lobophytum crassum led to the identification of a class of polyoxygenated cembrane-type macrocyclic diterpenes(1-28),including three new flexible cembranoids,...
关键词：Lobophytum crassum macrocyclic diterpenes cembranoids anticancer agent ROR1 ERBB3 
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity
《Chinese Journal of Natural Medicines》2024年第11期1003-1010,共8页WANG Mengru WANG Qi MA Yanzi ZEB Muhammad Aurang LI Xiaoli SHEN Feng XIAO Weilie 
supported by the National Natural Science Foundation of China(Nos.22477108,82260682);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);the Scientific Research Fund of Yunnan Provincial Department ofEducation(No.2023Y0235)。
Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-me...
关键词：Callicarpa integerrima Halimane diterpenes Clerodane diterpenes Structure elucidationanti-MRSA 
New pharmacological tools:the use of diterpenes to promote adult hippocampal neurogenesis被引量：1
《Neural Regeneration Research》2024年第8期1629-1630,共2页Ricardo Gomez-Oliva Pedro Nunez-Abades Carmen Castro 
supported by the Spanish Ministerio de Ciencio,Innovoción y Universidades(grant number RTI-2018-099908-B-C21 and RTI-2018-099908-B-C22 granted to CC);by the Consejería de Economia,Conocimiento,Empresas y Universidades(grant number FEDERUCA18-106647 granted to CC);by the Consejería de Salud y Familias 80%co-financed by EDRFITI regional funds(ITI-Cadiz-0042-2019 to CC)。
Tissue regeneration maintains homeostasis and preserves the functional features of each tissue.However,not all tissues show a strong repairing capacity.This is the case of the central nervous system.It is now well est...
关键词：capacity MAINTAIN preserve 
AbnI:Anα-ketoglutarate-dependent dioxygenase involved in brassicicene C-H functionalization and ring system rearrangement
《Chinese Chemical Letters》2024年第5期213-217,共5页Wenling Yuan Fengli Li Zhe Chen Qiaoxin Xu Zhenhua Guan Nanyu Yao Zhengxi Hu Junjun Liu Yuan Zhou Ying Ye Yonghui Zhang 
financially supported by the National Key R&D Program of China(Nos.2021YFA0910500,2021YFA0910503);the National Natural Science Foundation of China(Nos.22277035,32000045 and 81973205);the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Fundamental Research Funds for the Central Universities(No.2020kfyXJJS043).
We reported the characterization of a novel brassicicene diterpene biosynthetic gene cluster,which contains a uniqueα-ketoglutarate-dependent dioxygenase(αKGD)enzyme,AbnI.Our findings revealed that AbnI demonstrates...
关键词：Fungal diterpenes α-Ketoglutarate-dependent dioxygenase C-H functionalization REARRANGEMENT Brassicicenes 
Sustainable biosynthesis of valuable diterpenes in microbes
《Engineering Microbiology》2023年第1期65-79,共15页Yanbin Liu Xixian Chen Congqiang Zhang 
supported by the Agency for Science,Technology and Research(A∗STAR),Singapore:AME Young Individual Research Grant(YIRG)A2084c0064(Dr.Congqiang Zhang)and A1984c0040(Dr.Xixian Chen);A∗STAR Central Strategic Fund for the Singa-pore Integrative Biosystems and Engineering Research(SIBER)Program C211917009.
Diterpenes,or diterpenoids,are the most abundant and diverse subgroup of terpenoids,the largest family of sec-ondary metabolites.Most diterpenes possess broad biological activities including anti-inflammatory,antivira...
关键词：Diterpene/diterpenoid Secondary metabolites Synthetic biology Metabolic engineering BIOSYNTHESIS 
Zebrafish facilitates drug screening: potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae) as an anti-inflammatory agent被引量：1
《Journal of Traditional Chinese Medicine》2022年第5期749-757,共9页HE Xuemei XIAO Junjie FAN Chunlin LU Zibin CAO Huihui YU Linzhong ZHENG Yuanru LIU Junshan 
Supported by the National Science Foundation-funding Project:Study of the Attenuating Effects of 3-dehydroandrographolide on Acute Lung Injury through Modulating Alveolar Macrophage Polarization via Targeting α7n ACh R (No. 81973544);the Guangzhou Education Bureau University Scientific Research Project:Construction of Traditional Chinese Medicine Discipline (no. 201831845);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme:Study on the Mechanisms of Anti-Tumor and AntiInflammatory Components from Traditional Chinese Medicine based on Detoxification Therapy (No. GDHVPS2018);the Young Elite Scientists Sponsorship Program by CACM:Study on the Mechanisms of Antitumor Components from Traditional Chinese Medicine based on Detoxification Therapy (No. 2019-QNRC2-C14)。
OBJECTIVE: To systematically evaluate the in vivo antiinflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP). METHODS: We firstly adopted zebrafish, a novel and ideal anim...
关键词：diterpenes lactones INFLAMMATION ZEBRAFISH myeloid differentiation factor 88 NF-kappa B STAT3 transcription factor 
Cytotoxicity and Apoptosis Assay of Novel Cyclomyrsinol Diterpenes Against Breast Cancer Cell Lines被引量：2
《World Journal of Traditional Chinese Medicine》2022年第2期273-277,共5页Faezeh Rabbani Zeinab Yazdiniapour Mustafa Ghanadian Behzad Zolfaghari Melika Maleki Fatemeh Shafiee 
supported by the Pharmacy Student’s Research Committee,School of Pharmacy,Isfahan University of Medical Sciences(grant number:198018)。
Background:Cyclomyrsinane diterpenes especially those extracted from various Euphorbia species have shown interesting biological properties in recent years.Because of the high prevalence of breast cancer and the chall...
关键词：APOPTOSIS breast cancer cyclomyrsinol diterpenoids CYTOTOXICITY Euphorbia sogdiana Popov 
Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii被引量：3
《Acta Pharmaceutica Sinica B》2022年第6期2923-2933,共11页Lichan Tu Xinbo Cai Yifeng Zhang Yuru Tong Jian Wang Ping Su Yun Lu Tianyuan Hu Yunfeng Luo Xiaoyi Wu Dan Li Luqi Huang Wei Gao 
supported by the National Key R&D Program of China (No.2020YFA0908000);the Key Project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources (No.2060302-1806-03);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-D202005)。
Tripterygium wilfordii is a valuable medicinal plant rich in biologically active diterpenoids,but there are few studies on the origins of these diterpenoids in its secondary metabolism.Here,we identified three regions...
关键词：Tripterygium wilfordii Tandem duplication Diterpene synthases DIVERGENCE Secondary metabolism 
Au-Catalyzed 1,3-Acyloxy Migration/Cyclization Cascade:A Direct Strategy toward the Synthesis of Functionalized Abietane-Type Diterpenes
《CCS Chemistry》2021年第11期2795-2802,共8页Tian-Lu Zheng Si-Zhan Liu Chen-Yu Huo Jing Li Bo-Wen Wang Da-Ping Jin Fu Cheng Xiao-Ming Chen Xiao-Ming Zhang Xue-Tao Xu Shao-Hua Wang 
supported by the National Natural Science Foundation of China(nos.21472077 and 21772071);Department of Education of Guangdong Province(nos.2017KTSCX185,2017KSYS010,2016KCXTD005,and 2019KZDXM035).
A direct strategy toward the synthesis of functionalized abietane-type diterpenes and related polycyclic molecules was developed through an Au-catalyzed 1,3-acyloxy migration/cyclization/electrophilic aromatic substit...
关键词：polyene cyclization Au catalysis tandem reaction DITERPENE propargylic ester 
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new“non-natural”analogues被引量：1
《Acta Pharmaceutica Sinica B》2021年第9期2945-2956,共12页Ke Ma Yuting Zhang Cui Guo Yanlong Yang Junjie Han Bo Yu Wenbing Yin Hongwei Liu 
supported by the grants from the National Key R&D program of China(Grant 2018YFD0400203 and 2017YEE0108200);the National Natural Science Foundation of China(Grant 21472233);the“Innovative Cross Team”project,CAS(Grant E0222L01R1,China)
Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities.To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity,de novo synthesis...
关键词：Cyathane-type diterpene BIOSYNTHESIS Heterologous expression Non-enzymatic reaction 
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