HYPOGLYCEMIC

作品数：111被引量：301H指数：9
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Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic β cell regeneration and glucose uptake
《Chinese Journal of Natural Medicines》2025年第4期492-503,共12页Zhewei Yu Yi Zhang Wenhui Wang XinYi Wu Shunzhi Liu Yanlin Bin Hongsheng Li Bangping Cai Zheng Wang Meijuan Fang Rong Qi Mingyu Li Yingkun Qiu 
supported by the Traditional Chinese Medicine Foundation of Xiamen City,China(No.XWZY-2023-0303);the Natural Science Foundation of Xiamen City,China(No.3502Z20227162)。
In this study,araucarene diterpenes,characterized by a pimarene skeleton with a variably oxidized side chain at C-13,were investigated.A total of 16 araucarene diterpenoids and their derivatives were isolated from the...
关键词：Agathis dammara Araucarene DITERPENES HYPOGLYCEMIC Pancreatic β Cells 
Exploration of metformin-based drug combination for mitigating diabetes-associated atherosclerotic diseases
《World Journal of Diabetes》2025年第4期304-309,共6页Biao Qu Zheng Li Wei Hu 
Supported by the Natural Science Research Project of Anhui Province,No.2023AH053172;National Natural Science Foundation of Anhui Province,No.2408085QH260;Projects of Administration of Traditional Chinese Medicine of Anhui Province,No.2024CCCX082;National Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University,No.2022GMFY08.
Diabetes mellitus is a substantial global health threat due to its high prevalence and its serious complications.The hyperglycemic state causes damage to vascular endothelial cells and disturbance of lipid metabolism,...
关键词：Diabetes Atherosclerotic diseases METFORMIN Drug combination Hypoglycemic agent Hypolipidemic agent Antioxidant agent 
Tongmai Hypoglycemic Capsule Attenuates Myocardial Oxidative Stress and Fibrosis in the Development of Diabetic Cardiomyopathy in Rats
《Chinese Journal of Integrative Medicine》2025年第3期251-260,共10页ZENG Jie-qiong ZHOU Hui-fen DU Hai-xia WU Yu-jia MAO Qian-ping YIN Jun-jun WAN Hai-tong YANG Jie-hong 
Supported by National Key R&D Program for Modernization of Traditional Chinese Medicine(No.2018YFC1704204)。
Objective:To investigate the effect of Tongmai Hypoglycemic Capsule(THC)on myocardium injury in diabetic cardiomyopathy(DCM)rats.Methods:A total of 24 Sprague Dawley rats were fed for 4 weeks with highfat and high-sug...
关键词：Tongmai Hypoglycemic Capsule oxidative stress Nrf2 element myocardial fibrosis diabetic cardiomyopathy 
Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage
《Food Science and Human Wellness》2025年第1期112-123,共12页Xiaoxia Chen Chun Chen Changyang Ma Wenyi Kang Junlin Wu Xiong Fu 
The Guangdong Basic and Applied Basic Research Foundation(2022A1515010730);the National Natural Science Foundation of China(32001647);the Science and Technology Plan Projects of Guangzhou City(202102100009)(the Guangzhou Key Laboratory for Intelligent Sensing and Quality Control of Agricultural Products);National Natural Science Foundation of China(31972022);the 111 Project(B17018)to conduct the project are gratefully acknowledged。
The purpose of this study was to investigate the hypoglycemic effect and mechanism of D endrobium officinale polysaccharide(DOP)on type 2 diabetes mellitus(T2DM)mice established by high-fat diet and streptozotocin.The...
关键词：Dendrobium officinale polysaccharide HYPOGLYCEMIC MECHANISM LIPOPOLYSACCHARIDE Gut microbiota 
Glucagon-like peptide-1 and impaired counterregulatory responses to hypoglycemia in type 1 diabetes
《World Journal of Diabetes》2025年第2期297-304,共8页Gabriel Reis Rocha Fabrício Freire de Melo 
Industrial Technological Initiation Scholarship of National Council for Scientific and Technological Development,CNPq,No.0932204294929829;CNPq Research Productivity Fellow,No.4357511882624145.
This letter comments on a study by Jin et al,published recently in the World Journal of Diabetes.Hypoglycemia is a significant complication of diabetes,with primary defense mechanisms involving the stimulation of gluc...
关键词：Glucagon-like peptide 1 Type 1 diabetes mellitus Counterregulatory hypoglycemic dysfunction Hypoglycemia unawareness GLUCAGON Sympathoadrenal system 
Intestinal glucagon-like peptide-1 in hypoglycemic counterregulation for type 1 diabetes management
《World Journal of Diabetes》2024年第12期2380-2383,共4页Ke-Xin Zhang Cheng-Xia Kan Yu-Qun Wang Ning-Ning Hou Xiao-Dong Sun 
Type 1 diabetes(T1D)is characterized by the autoimmune destruction of pan-creatic beta cells,leading to absolute insulin deficiency and the need for exoge-nous insulin.A significant concern in T1D management is hypogl...
关键词：Type 1 diabetes Glucagon-like peptide-1 HYPOGLYCEMIA Hypoglycemic counterregulation Hormonal reaction 
Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events
《Acta Pharmaceutica Sinica B》2024年第6期2761-2772,共12页Zhipeng Zeng Runcheng Tan Shi Chen Haolin Chen Zhijia Liu Lixin Liu Mingqiang Li Yongming Chen 
supported by the National Natural Science Foundation of China(No.51820105004,China);the Key Areas Research and Development Program of Guangzhou(No.202007020006,China).
Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic index.Current long-acting insulin analogs...
关键词：Diabetes INSULIN Therapeutic index HYPOGLYCEMIA PEGYLATION Receptor-mediated clearance HALF-LIFE Diabetic nephropathy 
The Fang’s hypoglycemic formula improves insulin resistance in type 2 diabetes mellitus by regulating mitochondrial autophagy被引量：1
《Integrative Medicine Discovery》2024年第16期1-7,共7页Jia Zhu Xu-Dong Chen Jie Zhao 
supported by Applied Basic Research Project of Jiaxing Science and Technology Bureau(2023AD11047);the Joint Project of Yunnan Provincial Science and Technology Department and Yunnan University of Chinese Medicine(202101AZ070001-064).
Background:To investigate the pharmacological effects of Fangshi Jiangtang decoction(FSJT)on type 2 diabetes mellitus(T2DM)model rats and explore its mechanism of action from the perspective of mitochondrial autophagy...
关键词：Fangshi Jiangtang decoction type 2 diabetes mellitus mitochondrial autophagy oxidative stress 
Methods to Reduce the Hypoglycemic Mortality of Alloxan in Diabetic Rabbit Model
《Journal of Biosciences and Medicines》2024年第5期242-255,共14页Changtai Luo Dong Luo Luchang Chen Haidong Zhou Ruiqi Zhou Jihua Wei 
Objective: To explore an intervention method to reduce the mortality of alloxan diabetes model, and to preliminarily analyze the mechanism of alloxan induced animal death. Methods: Healthy New Zealand rabbits were ran...
关键词：ALLOXAN DIABETES Model RABBIT 
Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection被引量：1
《Chinese Herbal Medicines》2024年第1期151-161,共11页Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren Jiao Xiao Dongmei Wang Xiaoqiu Liu Yingni Pan 
the Fourth National Investigation of Chinese materia medica resources in Liaoning Province (LN2018017, LN2019019);Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (No. ZQN2021014);Key Laboratory of Marine Biogenetic Resources, Ministry of Natural Resources (No. HY202105)
Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic capacities.Methods: The AlCl3colorimetric method and...
关键词：anti-hyperglycemic activity ANTI-OXIDANT flowers of Xanthoceras sorbifolia Bunge NADPH oxidase off-line UPLC-QTOF-MS/MS-free radical scavenging 
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