This research was financially supported by the National Natural Science Foundation of China(Nos.22167010 and 81991521);the National Key Research and Development Program of China(No.2022YFC2804100);the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(No.23KJB350011);the Shandong Laboratory Program(SYS202205);the Basic Research Project of Guizhou University(No.2023-51).
A detailed chemical investigation of the Hainan soft coral Lobophytum crassum led to the identification of a class of polyoxygenated cembrane-type macrocyclic diterpenes(1-28),including three new flexible cembranoids,...
supported by the National Institutes of Health(NIH)grants(No.R01CA256791,R01CA264320,P50CA150964,P30CA043703).
How PD-L1 expression is regulated in cancer is poorly understood.Here,we report that the ATP-binding activity of ERBB3 pseudokinase regulates PD-L1 gene expression in colorectal cancers(CRCs).ERBB3 is one of the four ...