阿尔茨海默病患者脑动脉血流速度变化研究  

Variation of cerebral artery blood flow velocity in AD patients

作　　者：金旺盛[1] 曾凡[1] 刘雨辉 卜先乐 姚秀卿[1] 曹红元[1] 王叶冉[1] 陈阳[1] 张涛[1] 王延江[1] JIN Wang-sheng ZENG Fan LIU Yu-hui BU Xian-le YAO Xiu-qing CAO Hong-yuan WANG Ye-ran CHEN Yang ZHANG Tan WANG Yan-jiang(Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, Chin)

机构地区：[1]第三军医大学大坪医院神经内科,重庆400042

出　　处：《中国医学前沿杂志（电子版）》2016年第11期12-14,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：科技部"重大慢性非传染性疾病防控研究"重点专项(2016YFC1306401)

摘　　要：目的通过经颅多普勒(transcranial Dopple,TCD)检查获得阿尔茨海默病(Alzheimer's disease,AD)患者与正常研究对象的脑动脉平均血流速度,探究AD患者脑动脉平均血流速度的变化。方法选取2014年7月至2016年7月于本院就诊的20例AD患者纳入AD组,同时选取本院体检中心同期与AD组患者年龄和性别相匹配的20例正常健康人纳入对照组,通过TCD检查基底动脉和左、右颈内动脉的平均血流速度。采用t检验比较两组研究对象各血管的平均血流速度。结果 AD组患者基底动脉和左颈内动脉平均血流速度均明显低于对照组(P<0.05),而右颈内动脉平均血流速度虽然低于对照组,但无显著差异(P>0.05)。结论 AD患者存在中枢血流动力学降低,提示中枢低灌注引起的缺血缺氧可能是促进AD发生发展的危险因素。Objective Transcranial Doppler （TCD） measurement was used to explore the changes of cerebral artery blood flood rate in Alzheimer＇s disease （AD） patients. Method TCD measurement data was collected from 30 AD patients （AD group） and 24 matched normal subjects investigated （control group） from July 2014 to July 2016 in our hospital, t-test was used to compare the mean velocity of blood flow in basitar artery, left and right internal carotid arteries between AD group and control group. Result Compared with control group, the velocity of blood flow in basilar artery and left internal carotid artery were slower in AD group patients （P 〈 0.05）. AD group patients had slower blood flow than control group patients, but the difference did not reach statistical significance （P 〉 0.05）. Conclusion Slower cerebral flow in AD patients suggests that hypopcrfusion and hypoxia might be involved in the pathogenesis of AD.

关 键 词：阿尔茨海默病 经颅多普勒 平均血流速度 大脑低灌注 

分 类 号：R749.16[医药卫生—神经病学与精神病学]