应用基因工程技术增强间充质干细胞移植效果  

Genetic engineering techniques to enhance therapeutic effects of mesenchymal stem cells

作　　者：张金梅[1] 杨远荣[1] 熊建群[1] 丁卓玲[1] Zhang Jinmei Yang Yuanrong Xiong Jianqun Ding Zhuoling.(Department of Pharmacy in Jingzhou Centre Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434020, Chin)

机构地区：[1]华中科技大学同济医学院附属荆州医院药学部,荆州434020

出　　处：《中华细胞与干细胞杂志（电子版）》2016年第5期312-315,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：间充质干细胞(MSCs)在再生医学领域应用前景无限。它取材较容易,无论是天然的还是通过细胞工程诱导获得的均具有多向分化能力。成功的MSCs治疗依赖于有效的细胞输送和移植细胞的长期存活,以便能长久地在目标位点更多地发挥效应。在MSCs移植前应用基因工程技术对其进行修饰可取得这一效果。本文介绍了能提高移植MSCs的迁移能力、防止MSCs衰老和凋亡及提高MSCs存活率的基因工程方法策略。Mesenchymal stem cells （MSCs） are promising in the field of regenerative medicine due to their relatively easy access and multidifferentiation capabilities, either naturally or induced through cell engineering. Successful MSCs treatment depends on efficient methods of cell delivery and the long-term survival of grafted cells at the target site. The application of genetic engineering technology to modify MSCs before transplantation can accomplish long-term survival. In this review, we describe the genetic engineering strategies to increase the migration ability, decrease senescence and apoptosis and improve the survival of transplantated MSCs.

关 键 词：间质干细胞 基因工程 细胞移植 细胞运动 细胞存活 

分 类 号：R457.7[医药卫生—治疗学]