Pygo2蛋白在肿瘤中作用机制的研究进展  

Role of Pygo2 in tumors

作　　者：秦文英[1] 吕林月 周策凡 陈兴珍[1] 唐景峰[1] 

机构地区：[1]湖北工业大学生物工程与食品学院生物医药研究院,湖北省武汉市430068

出　　处：《世界华人消化杂志》2016年第34期4589-4595,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81602448~~

摘　　要：Pygo2蛋白作为Wnt信号通路下游一个重要的新功能蛋白,已发现同多种肿瘤的发生有着密切的关系.Pygo2包含NHD和PHD结构域,其中NHD是该蛋白特有的结构域,能够结合组蛋白甲基化转移酶和乙酰酶,并且协同PHD共同结合甲基化组蛋白,改变染色体的结构,激活Wnt靶基因.但是Pygo2蛋白在肿瘤发生过程中的具体分子机制并不清楚,故本文对Pygo2的结构及其与肿瘤的相关性进行综述,拟阐明Pygo2蛋白在肿瘤的发生发展过程中所扮演的角色及其致病机制.Pygo2,a vital component of the Wnt signaling pathway that was recently discovered,has been reported to be closely related to the tumorigenesis of several types of malignant tumors.There are two highly conservative domains named NHD in the N terminus and PHD in the C terminus of Pygo2.Previous studies have shown that the Pygo2 PHD domain can act as a protein code reader to link the chromatin remodeling complex to specific changes in gene transcription,as demonstrated for the Wnt target genes.Furthermore,the activity of the chromatin remodeling is further facilitated by the recruiting of histone methyltransferase and acetyltransferase through the interaction with the Pygo2 NHD domain.However,the molecular mechanism of Pygo2 in the tumor development is still poorly understood.In the present study,we intend to review the structure and role of Pygo2 in tumor progression.

关 键 词：PYGO2 WNT信号通路 肿瘤 APC 

分 类 号：R730.2[医药卫生—肿瘤]