Mac-2结合蛋白糖基化异构体在慢性肝病诊断中的作用  

Role of the Mac-2 binding protein glycosylation isomer in diagnosis of chronic liver diseases

作　　者：杨以良 崔园园[1] 胡月[1] 徐洪芹 潘煜[1] 

机构地区：[1]吉林大学第一医院肝胆胰内科,长春130021

出　　处：《临床肝胆病杂志》2016年第12期2395-2398,共4页Journal of Clinical Hepatology

基　　金：吉林大学第一医院青年发展基金(JDYY52015025)

摘　　要：Mac-2结合蛋白(M2BP)是存在于胞浆、组织液和血浆中的一类糖蛋白,可由多种组织器官分泌。Mac-2结合蛋白糖基化异构体(M2BPGi)由肝星状细胞合成,简述了M2BPGi在慢性肝病中的研究现状,发现血清M2BPGi水平有助于提高肝脏病变诊断、监测的特异度和敏感度,较其他无创方法具有一定的优势,有望成为肝脏病变诊断的新型生物学标志物。Mac- 2 binding protein is a type of glycoprotein which exits in cytoplasm,interstitial fluid,and plasma and is secreted by a variety of tissues and organs. Mac- 2 binding protein glycosylation isomer（ M2BPGi） is synthesized by hepatic stellate cells. This article briefly introduces the research advances in the role of M2 BPGi in chronic liver diseases and finds out that the serum level of M2 BPGi helps to increase the specificity and sensitivity of the diagnosis and monitoring of liver diseases,has certain advantages over other noninvasive methods,and may become a new biological marker for the diagnosis of liver diseases.

关 键 词：肝疾病 生物学标记 糖蛋白类 诊断 综述 

分 类 号：R575[医药卫生—消化系统]