不同亚型功能性消化不良患者血清CRF水平及其与焦虑/抑郁的关系  

The difference of CRF level and its relationship with anxiety/depression in subgroups of functional dyspepsia

作　　者：李慧[1] 汤海涛[1] 王修中[1] 徐陈[1] LI Hui TANG Hai-tao WANG Xiu-zhong XU Chen(Department of Gastrointestinal Endoscope,Anhui Medical University Affiliated Chamber Lu＇an Hospital,Lu＇an Anhui 237000,Chin)

机构地区：[1]安徽医科大学附属六安医院胃肠镜室,安徽六安237000

出　　处：《临床消化病杂志》2016年第6期333-337,共5页Chinese Journal of Clinical Gastroenterology

摘　　要：[目的]评估不同亚型功能性消化不良(functional dyspepsia,FD)患者血清促肾上腺皮质激素释放因子(corticotrophin releasing factor,CRF)水平差异及其与焦虑/抑郁的关系。[方法]根据罗马Ⅲ诊断标准,将66例FD患者分为餐后不适综合征(PDS)组(22例)、上腹痛综合征(EPS)组(22例)和PDS重叠EPS组(22例),并设立正常对照组(30例)。收集病例资料,根据FD症状量化积分评定症状严重程度,采用汉密尔顿焦虑/抑郁量表(HAMA/HAMD)评估FD患者各组焦虑/抑郁状态。采用竞争酶联免疫吸附(ELISA)试验检测血清CRF浓度,并比较各组间差异。[结果]FD患者各组血清CRF平均浓度均高于正常对照组(P<0.01),但FD患者各组间差异无统计学意义(P>0.05);FD患者各组中伴焦虑/抑郁者血清CRF平均浓度均高于不伴焦虑/抑郁者(P<0.05);CRF浓度与FD患者FD症状量化积分或HAMA/HAMD评分均呈正相关性(P<0.05)。[结论]FD患者血清CRF水平较正常人增高,血清CRF浓度的增加与FD患者焦虑/抑郁行为有关,CRF可能参与FD的发生、发展。[Objective]To evaluate the serum corticotrophin releasing factor（CRF）level in different sub- groups of functional dyspepsia patients, and its relationship with anxiety/depression state. [Methods]Ac- cording to Rome Ⅲ diagnostic criteria, 66 cases of patients with functional dyspepsia were divided into three groups,which included postprandial distress syndrome（PDS）（22 cases）, epigastric pain syndrome （EPS） （22 cases）and PDS overlapping EPS（22 cases）. Thirty health subjects were involved as healthy con- trol group. The data of those cases were collected, FD severity was assessed by quantitative index of FD symptoms, the anxiety/depression state was screened with the Hamilton Anxiety Scale（HAMA）and Ham- ilton Depression Scale（HAMD）. The patients in every group were divided into with or without anxiety/de- pression. By using competitive enzyme-linked immuno-sorbent assay（ELISA）, the serum concentrations of CRF was measured. [Results]The serum CRF average concentrations in every group of the three subgroups were higher than that in the healthy controls（P^0.01）. There were no statistically significant difference a- mong the three subgroups（P）0.05）. The serum CRF were higher in patients with anxiety/depression comparing to the patients without anxiety/depression（P（0.05）. CRF concentration was positively correla- ted to quantitative index of FD symptoms and HAMA/HAMD scores. [Conclusion] FD patients have a higher serum CRF level than the normal people, the serum CRF concentration has a relationship with anxi ety/depression behavior in FD patients and may participate in the development of FD.

关 键 词：功能性消化不良 餐后不适综合征 上腹痛综合征 促肾上腺皮质激素释放因子 症状量化积分 焦虑/抑郁 

分 类 号：R574.4[医药卫生—消化系统]