咪喹莫特在皮肤肿瘤中的应用与机制  

Application and mechanism of imiquimod in skin tumor

作　　者：张付贺 石磊[2] 罗敏[1,2] 王秀丽[2] Zhang Fuhe Shi Lei Luo Min Wang Xiuli(Department of Photomedicine, Shanghai Skin Disease Clinical College of Anhui Medical University, Department of Photomedicine, Shanghai Skin Disease Hospital, Tonal University School of Medicine Institute of Photomedicine, Shanghai 200443, Chin)

机构地区：[1]安徽医科大学上海皮肤病临床学院光医学治疗科,上海200443 [2]上海市皮肤病医院 同济大学医学院光医学研究所光医学治疗科

出　　处：《国际肿瘤学杂志》2016年第12期953-955,共3页Journal of International Oncology

基　　金：国家自然科学基金（81472796）;上海市青年科技英才扬帆计划（15YF1410700）

摘　　要：咪喹莫特是一种人工合成的 Toll 样受体-7激动剂，在皮肤科主要用于治疗基底细胞癌、鳞状细胞癌、皮肤转移性黑色素瘤和外阴上皮内瘤变，具有激活天然免疫和特异性免疫、诱导肿瘤细胞自噬和凋亡、抑制肿瘤血管的形成等作用，有着极大的临床应用潜力。Imiquimod is a synthetic Toll-like receptor-7 agonist,mainly used for the treatment of basal cell carcinoma,squamous cell carcinoma and metastatic melanoma and vulvar intraepithelial neoplasia.Since imiquimod has activated innate immunity and specific immunity,inducing tumor cells autophagy and apoptosis, inhibit the formation of tumor blood vessels and other effects,it will has a great potential clinical application in the future.

关 键 词：肿瘤 免疫 咪喹莫特 

分 类 号：R739.5[医药卫生—肿瘤]