AKT2过表达与非小细胞肺癌预后的相关性研究  

Correlation between the overexpression of AKT2 and the prognosis of non-small cell lung cancer

作　　者：张敏[1] 陈秀美[1] 薛艳[2] 

机构地区：[1]莱芜市人民医院检验科,山东莱芜271199 [2]莱芜市人民医院病理科,山东莱芜271199

出　　处：《癌症进展》2016年第11期1135-1137,共3页Oncology Progress

摘　　要：目的研究AKT2在非小细胞肺癌(NSCLC)组织中的表达及与患者预后的关系。方法应用免疫组织化学方法检测80例NSCLC患者组织中AKT2表达,采用Kaplan-Meier法分析AKT2表达与患者预后的关系。结果 NSCLC患者组织中AKT2在腺癌中的阳性表达率是46.7%,鳞癌中的阳性表达率是46.0%,两者比较差异无统计学意义(P﹥0.05);AKT2的表达与患者性别、年龄、肿瘤大小、分期、淋巴结转移及细胞分化方面差异无统计学意义(P﹥0.05)。生存分析显示AKT2高表达的NSCLC患者5年生存率与低表达者比较差异有统计学意义。结论 AKT2过度表达的肺癌患者出现早期肿瘤转移的几率高,其5年生存率降低,可作为NSCLC预后的标志物。Objective To investigate the association between AKT2 expression and the prognosis of non-small cell lung cancer （NSCLC） patients. Method Immunohistochemistry （IHC） assay was applied to measure the AKT2 protein levels in 80 NSCLC patients, and the correlation between AKT2 expression and patients＇ prognosis was evaluated by Ka-plan-Meier plot. Result The positive expression rate of AKT2 was 46.2%in the NSCLC cohort, and was 46.0%in squa-mous cell carcinoma tissues, thus no significant difference was observed （P〉0.05）;There was no significant correlations between gender, age, tumor size, stage, lymph node metastasis or cell proliferation and AKT2 expression （P〉0.05）. The survival analysis showed that the 5-year survival rate in patients with high and low expression of AKT2 was of statistical-ly significant difference. Conclusion The overexpression of AKT2 in NSCLC patients represents higher potential of ear-ly metastasis, and lower 5-year survival rate, which may be used as prognostic factors for NSCLC.

关 键 词：非小细胞肺癌 AKT2过表达 相关性 预后 

分 类 号：R734.2[医药卫生—肿瘤]