趋化素样因子超家族8研究进展  

Research Advances in Chemokine-like Factor Super Family Member 8

作　　者：高等会 胡浩[1] 方志伟[1] 霍飞[1] 王焕瑞 许克新[1] 王晓峰[1] 

机构地区：[1]北京大学人民医院泌尿外科,北京100044

出　　处：《中国医学科学院学报》2016年第6期746-749,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81272830)~~

摘　　要：趋化素样因子超家族(CMTM)是北京大学人类疾病基因研究中心在国际上首次报道的新基因家族,CMTM8是该家族成员,其基因编码产物具有潜在的4次跨膜蛋白结构,是一个新的肿瘤抑制基因。CMTM8在多数肿瘤细胞系和组织中表达明显下调或不表达,过表达可抑制肿瘤细胞的增殖、迁移和侵袭功能。CMTM8抗肿瘤的机制尚未完全明确,可能参与多个与癌症发生发展密切相关的信号通路。对CMTM8与肿瘤发生发展机制的进一步研究具有重要意义,其有望成为肿瘤基因治疗的新靶标。Chemokine-like factor super family member（ CMTM） is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM8 is one member of this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily.CMTM8 is down-regulated in most carcinoma cell lines and tissues. Over-expression of CMTM8 may inhibit the proliferation,migration,and invasion of carcinoma cells. However,the exact mechanism of its anti-tumor activity remains unclear. CMTM8 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM8 may be a new target in the gene therapies for tumors,while further studies on CMTM8 and its anti-tumor mechanisms are warranted.

关 键 词：趋化素样因子超家族8 4次跨膜蛋白超家族 肿瘤抑制基因 

分 类 号：R394[医药卫生—医学遗传学]